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Aiwen Lei

 Prof. Aiwen Lei  
College of Chemistry and Molecular Sciences
  The Institute for Advanced Studies
  Wuhan University, Wuhan, 430072 (P. R. China)
  Fax: (+86)27-6875-4672
  E-mail: aiwenlei@whu.edu.cn

  Prof. Aiwen Lei (08/1973)
  ORCID 0000-0001-8417-3061
  ResearcherID G-8033-2015
  Scopus Author ID 7003632949

  Prof. Lei’s author profile published on Angew.Chem.Int.Ed., 2011, 12136.

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Education

  Ph. D., Organic Chemistry, July, 2000, Shanghai Institute of Organic Chemistry, Chinese Academy of Science (CAS), China Supervisor – Prof. Xiyan Lu

  B.S., Chemistry Education, July, 1995, Huaibei Normal University, Huaibei, AnHui Province, P. R. China
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Research Experience

·        2005.3- Professor of Wuhan University

·        2003.8-2005.3, Research Associate, Department of Chemistry, Stanford University, with Professor James, P. Collman

·        2000.8-2003.8 Postdoctoral Fellow, Department of Chemistry, the Pennsylvania State University, with Professor Xumu Zhang

·        1995.9-2000.7 Graduate Studies, Shanghai Institute of Organic Chemistry, CAS, China (SIOC)

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Selected Awards

·   The Third Batch of National Million Plan Leader, 2017

·   Overseas Chinese (Innovative Talents) Contribution Award, 2016

·   The National Youth Science and Technology Innovation Talents, 2015

·   The Roche Chinese Young Investigator Award, 2015

·   Fellow of the Royal Society of Chemistry, FRSC, 2015

·   Yangtse River Scholar Distinguished Professor, 2014

·   Second-Class Natural Science Award of Liaoning Province, 2014

·   Overseas Chinese (Innovative Talents) Contribution Award, 2014

·   Youth Chemist Award of the Chinese Chemical SocietyPhysical Organic Chemistry, 201

·   Committee of the Chinese Physical Organic Chemical Society, 2014

·   Chinese Chemistry SocietyRoyal Society of Chemistry Young Chemist Award, 2014

·   Guest Professor, University of Münster, 2013

·   Asian Rising Stars (15th ACC Meeting), 2013

·   Hubei Province Youth Medal, 2013

·   NanKai University Lectureship on Organic Chemistry,2013

·   First-Class Natural Science Award of Hubei Province, 2012

·   Eli Lilly Scientific Excellence Award in Chemistry, 2011

·   Lectureship Award under the New Phase Asian Core Program on Cutting-Edge Organic Chemistry in Asia, Singapore, 2011

·   Lectureship Awardee of Asian International Symposium for Outstanding Young Scientists, 2011

·   Lectureship Award under the New Phase Asian Core Program on Cutting-Edge Organic Chemistry in Asia, Japan, 2011

·   National Science Fund for Distinguished Young Scholars, China, 2010

·   CAPA (Chinese-American Chemistry & Chemical Biology Professors Association) Distinguished Faculty Award, 2009

·   Chinese Chemistry SocietyJohn Wiley Young Chemist Award, 2008 

·   Royal Society Chemistry Journal Grant, 2008

·   Synthesis & Synlett  Journal Award, 2008

·   Wuxi Pharmtech Biological & Organic Creative Award, 2007

·   Luojia Scholarship Professor (Wuhan University), 2007

·   Outstanding Young Scientist of Hubei Province, 2006

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Book Chapters

 

1)      Lei, A. W.; Jin, L. Q. Case Study of Mechanisms in Synthetic Reactions in Organic Chemistry – Breakthroughs and Perspectives, eds. Ding, K. L.; Dai, L.X. Wiley-VCH, Weinheim, 2012, August
2)      Lei, A. W.; Zhang, H. Transition Metal-Catalysed Direct Arylation of Unactivated Arenes with Aryl Halides in C-H and C-X Bond Functionalization: Transition Metal Mediation,Ed. Ribas, X. RSC, 2013

3)      He, C.; Lei, A. W. Application of Nontoxic Iron Salts in Oxidative C-C Coupling Reactions in Comprehensive Inorganic Chemistry II, eds. Reedijk, J. and Poeppelmeier, K., Vol 6. Oxford: Elsevier; 2013. p. 521-547.
 
4)   Lei, A. W.W.; Liu, W. Directed Aryl C-H Oxidations with Transition Metals. In: Molander and Paul Knochel (eds.), Comprehensive Organic Synthesis, 2nd edition, Vol 7, Oxford: Elsevier; 2014. PP. 313-346

5)      Lei, A. Shi, W. Liu, C. Liu, W. Zhang, H. He, C. Oxidative Cross-Coupling Reactions. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527680986.

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Selective Publications

 

1)      Xia Hu, Guoting Zhang, Faxiang Bu and Aiwen Lei. Selective Oxidative [4+2] Imine/Alkene Annulation with H2 Liberation Induced by Photo-Oxidation. Angew. Chem. Int. Ed. 2018, DOI: 10.1002/anie.201711359

2)      Kun Liu, Shan Tang, Pengfei Huang, Aiwen Lei. External oxidant-free electrooxidative [3 + 2] annulation between phenol and indole derivatives. Nature Commun. 2017, 8, 775.
3)      Shan Tang, Yichang Liu and Aiwen Lei. Electrochemical Oxidative Cross-Coupling with Hydrogen Evolution: A Green and Sustainable Way for Bond Formation. Chem 2018, 4, DOI: 10.1016/j.chempr.2017.10.001
4)      Wang, H. M.; Lu, Q. Q.; Chiang, C. W.; Luo, Y.; Zhou, J. F.; Wang, G. Y.; and Lei, A. W.; Markovnikov-Selective Radical Addition of S-Nucleophiles to Terminal Alkynes via Photoredox Process, Angew. Chem. Int. Ed. 2017, 129, 610-614

5)      Yi, H.; Niu, L. B.; Song, C. L.; Li, Y. Y.; Dou, B. W.; Singh, A. K.; Lei, A. W.;  Photocatalytic Dehydrogenative Cross-Coupling of Alkenes with Alcohols or Azoles without External Oxidant, Angew. Chem. Int. Ed. 2017, 56, 1120 –1124.

6)      Wang, P.; Tang, S.; Huang, P. F.; Lei, A. W.; Electrocatalytic Oxidant-Free Dehydrogenative C-H/S-H Cross Coupling, Angew. Chem. Int. Ed. 2017, 56, 3009-3013.

7)      Niu, L. B.; Yi, H.; Wang, S. C.; Liu, T. Y.; Liu, J. M.; Lei, A. W.; Photo-induced oxidant-free oxidative C–H/N–H cross-coupling between arenes and azoles, Nature Commun., 2017, 8, DOI: 10.1038/ncomms14226.

8)      Yi, H.; Yang, D. L.; Xin, J.; Qi, X. T.; Lan, Y.; Deng, Y.; Pao, C. W.; Lee, J. F.; Lei, A. W.; Unravelling the hidden link of lithium halides and application in the synthesis of organocuprates, Nature Commun., 2017, 8, DOI: 10.1038/ncomms14794

9)      Yi, Hong; Zhang, Guoting; Wang, Huamin; Huang, Zhiyuan; Wang, Jue; Singh, Atul K.; Lei, Aiwen, Recent Advances in Radical C-H Activation/Radical Cross-Coupling. Chem. Rev. 2017, 117, 9016 – 9085.

10)   Crabtree, Robert H.; Lei, Aiwen, Introduction: C-H Activation. Chem. Rev. 2017, 117, 8481 – 8482.

11)   Matthew S. Kirschner, Wendu Ding, Yuxiu Li, Craig T. Chapman, Aiwen Lei, Xiao-Min Lin, Lin X. Chen, George C. Schatz, and Richard D. Schaller. Phonon-Driven Oscillatory Plasmonic Excitonic Nanomaterials. Nano Lett. 2017, DOI: 10.1021/acs.nanolett.7b04354.

12)   Wang, H. M.; Lu, Q. Q.; Qian, C. H.; Liu, C.; Liu, W.; Chen, K.; Lei, A. W., Solvent Enabled Radical Selectivities: Controlled Syntheses of Sulfoxides and Sulfides. Angew. Chem. Int. Ed., 2016, 55, 1094-1097.

13)   Wu. Q.; Luo, Y.; Lei, A. W.; You, J. S., Aerobic Copper-Promoted Radical-Type Cleavage of Coordinated Cyanide Anion: Nitrogen Transfer to Aldehydes to Form Nitriles. J. Am. Chem. Soc.2016138 (9), 2885–2888.

14)   Tang, S.; Wang, P.; Li, H.; Lei, A. W., Multimetallic catalysed radical oxidative C(sp3)–H/C(sp)–H cross-coupling between unactivated alkanes and terminal alkynes, Nature communications 2016, 7, 11676, DOI:10.1038/ncomms11676

15)   Zhang, G. T.; Hu, X.; Chiang, C. W.; Yi, H.; Pei, P. K.; Singh, K, Atul.; Lei, A. W.,  Anti-Markovnikov Oxidation of β-Alkyl Styrenes with H2O as the Terminal Oxidant, J. Am. Chem. Soc., 2016, 138, 12037−12040

16)   Wu Li, Zhengli Duan, Xueye Zhang, Heng Zhang, Mengfan Wang, Ru Jiang, Hongyao Zeng, Chao Liu and Aiwen Lei, From Anilines to Isatins: Palladium-Catalyzed Oxidative C−H Double Carbonylation. Angew. Chem. Int. Ed. 2015, 54, 1893-1896.

17)   Jianming Liu, Xin Zhang, Hong Yi, Chao Liu, Ren Liu, Heng Zhang, Kelei Zhuo, and Aiwen Lei. Chloroacetate-Promoted Selective Oxidation of Heterobenzylic Methylenes under Copper Catalysis. Angew. Chem. Int. Ed. 2015, 54, 1261–1265.

18)   Shan Tang, Kun Liu, Chao Liu, and Aiwen Lei, Olefinic C-H functionalization through radical alkenylation. Chem. Soc. Rev. 2015, 44(5), 1070-1082.

19)   Ke, J.; Tang, Y. L.; Yi, H.; Li, Y. L.; Cheng, Y. D.; Liu, C.; Lei, A. W., Copper-Catalyzed Radical/Radical C(sp3)-H/P-H Cross-Coupling: α-Phosphorylation of Aryl Ketone O-Acetyloximes. Angew. Chem. Int. Ed., 2015, 54, 6604-6607.

20)   Zhang, G. T.; Liu, C.; Yi, H.; Meng, Q. Y.; Bian, C. L.; Chen, H.; Jian, J. X.; Wu, L. Z.; Lei, A. W., External Oxidant-Free Oxidative Cross-Coupling: A Photoredox Cobalt-Catalyzed Aromatic C-H Thiolation for Constructing C-S Bonds. J. Am. Chem. Soc. 2015, 137, 9273–9280.

21)   Tang, S.; Zeng, L.; Liu, Y. C.; Lei, A. W., Zinc-Catalyzed Dehydrogenative Cross-Coupling of Terminal Alkynes with Aldehydes: A Simple Access to Ynones. Angew. Chem. Int. Ed. 2015, 54, 15850 –15853.

22)   Liu, C.; Yuan, J. W.; Gao, M.; Tang, S.; Li, W.; Shi, R. Y.; Lei, A. W., Oxidative Coupling between Two Hydrocarbons: An Update of Recent C-H Functionalizations. Chem. Rev.2015115 (22), 12138–12204.

23)   Wu, K.; Huang, Z. L.; Qi, X. T.; Li, Y. Z.; Zhang, G. H.; Liu, C.; Yi, H.; Meng, L. K.; Bunel, E. E.; Miller, J. T.; Pao, C. W.; Lee, J. F.; Lan, Y.; Lei, A. W., Copper-Catalyzed Aerobic Oxidative Coupling: From Ketone and Diamine to Pyrazine. Sci. Adv. 2015, Vol. 1, no. 9, e1500656. DOI: 10.1126/sciadv.1500656.

24)   Zhang, G.H.; Yi, H.; Zhang, G.T.; Deng, Y.; Bai, R.P.; Zhang, H.; Miller, J.T.; Kropf, A.J.; Bunel, E.E.; Lei, A. W., Direct Observation of Reduction of Cu(II) to Cu(I) by Terminal Alkynes. J Am Chem Soc 2014, 136, 924-926 

25)   Liu, J.; Liu, Q.; Yi, H.; Qin, C.; Bai, R. P.; Qi, X. T.; Lan, Y.; Lei, A. W., Visible Light Mediated Decarboxylation / Oxidative Amidation of α-Keto Acids with Amines under Mild Conditions Using O2. Angew Chem Int Ed 2014, 53, 502

26)   Li, W.; Liu, C.; Zhang, H.; Ye, K.Y.; Zhang, G.H.; Zhang, W.Z.; Duan, Z.L.; You, S.L.; Lei, A. W., Palladium-Catalyzed Oxidative Carbonylation  of N-allylamines for the synthesis of â-lactams. Angew Chem Int Ed 2014, 53, 2443

27)   Wang, L.; Wang, Y.X.; Liu, C.; Lei, A. W., CO/C-H as the Acylative Reagent: A Palladium-Catalyzed Aerobic Oxidative Carbonylative Esterfication of Alcohols. Angew Chem Int Ed 2014, 53, 5657

28)   Ruopeng Bai, Guanghui Zhang, Hong Yi, Zhiliang Huang, Xiaotian Qi, Chao Liu, Jeffrey T Miller, Arthur Jeremy Kropf, Emilio E Bunel, Yu Lan, and Aiwen Lei. Cu(II)/Cu(I)-Synergistic Cooperation to Lead the Alkyne C-H Activation. J. Am. Chem. Soc., 2014, 136, 16760–16763.

29)   Liu, C.; Liu, D.; Lei, A. W., Recent Advance of Transition-Metal Catalyzed Radical Oxidative Cross-Couplings. Acc. Chem. Res. 2014, 47, 3459−3470.

30)   He, C.; Zhang, G. H.; Ke, J.; Zhang, H.; Miller, J. T.; Kropf, A. J.; Lei, A. W., Labile Cu(I)-Catalyst/Spectator Cu(II)-Species in Copper-Catalyzed C-C Coupling Reaction: Operando IR, In situ XANES/EXAFS Evidence and Kinetic Investigations. J Am Chem Soc 2013, 135, 488

31)   Lu, Q. Q.; Zhang, J.; Zhao, G. L.; Qi, Y.; Wang, H. M.; Lei, A. W., Dioxygen-Triggered Oxidative Radical Reaction: Direct Aerobic Difunctionalization of Terminal Alkynes towards β-Keto Sulfones. J Am Chem Soc  2013, 135, 11481

32)   Muto, K.; Yamaguchi, J.; Lei, A. W.; Itami, K., Isolation, Structure, and Reactivity of an Arylnickel(II) Pivalate Complex in Catalytic C-H/C-O Biaryl Coupling. J Am Chem Soc  2013, 135, 16384

33)   He, C.; Ke, J.; Xu, H.; Lei, A. W., Insights toward the Symbiotic Catalysis Sonogashira Coupling Reaction: Quantitative Kinetic Investigation of Transmetalation.  Angew Chem Int Edit  2013, 52, 1527

34)   Wang, J.; Liu, C.; Yuan, J. W.; Lei, A. W., Copper-Catalyzed Oxidative Coupling of Alkenes with Aldehydes: Direct Access to α, β-unsaturated Ketones. Angew Chem Int Edit 2013, 52, 2256

35)   Liu, D.; Liu, C.; Li, H.; Lei, A. W., Direct Funtionalization of Tetrahydrofuran and 1,4-Dioxane: A Nickel-Catalyzed Oxidative Csp3-H Arylation. Angew Chem Int Ed 2013, 52, 4453

36)   Gao, M.; He, C.; Chen, H. Y.; Bai, R. P.; Cheng, B.; Lei, A. W., Synthesis of Pyrrole by Click Reaction: Silver-Catalyzed Cycloaddition of Terminal Alkynes with isocyanides. Angew Chem Int Edit 2013, 52, 6958

37)   Huang, Z. L.; Jin, L. Q.; Feng, Y.; Peng, P.; Yi, H.; Lei, A. W., Iron-Catalyzed Oxidative Radical Cross-Coupling/Cyclization between Phenol and Olefin. Angew Chem Int Edit 2013, 52, 7151