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Aiwen Lei

 Prof. Aiwen Lei  
College of Chemistry and Molecular Sciences
  The Institute for Advanced Studies
  Wuhan University, Wuhan, 430072 (P. R. China)
  Fax: (+86)27-6875-4672
  E-mail: aiwenlei@whu.edu.cn

  Prof. Aiwen Lei (08/1973)
  ORCID 0000-0001-8417-3061
  ResearcherID G-8033-2015
  Scopus Author ID 7003632949

  Prof. Lei’s author profile published on Angew.Chem.Int.Ed., 2011, 12136.



  Ph. D., Organic Chemistry, July, 2000, Shanghai Institute of Organic Chemistry, Chinese Academy of Science (CAS), China Supervisor – Prof. Xiyan Lu

  B.S., Chemistry Education, July, 1995, Huaibei Normal University, Huaibei, AnHui Province, P. R. China

Research Experience

·        2005.3- Professor of Wuhan University

·        2003.8-2005.3, Research Associate, Department of Chemistry, Stanford University, with Professor James, P. Collman

·        2000.8-2003.8 Postdoctoral Fellow, Department of Chemistry, the Pennsylvania State University, with Professor Xumu Zhang

·        1995.9-2000.7 Graduate Studies, Shanghai Institute of Organic Chemistry, CAS, China (SIOC)


Selected Awards

·   The Third Batch of National Million Plan Leader, 2017

·   Overseas Chinese (Innovative Talents) Contribution Award, 2016

·   The National Youth Science and Technology Innovation Talents, 2015

·   The Roche Chinese Young Investigator Award, 2015

·   Fellow of the Royal Society of Chemistry, FRSC, 2015 

·   Second-Class Natural Science Award of Liaoning Province, 2014

·   Overseas Chinese (Innovative Talents) Contribution Award, 2014

·   Youth Chemist Award of the Chinese Chemical SocietyPhysical Organic Chemistry, 201

·   Committee of the Chinese Physical Organic Chemical Society, 2014

·   Chinese Chemistry SocietyRoyal Society of Chemistry Young Chemist Award, 2014

·   Guest Professor, University of Münster, 2013

·   Asian Rising Stars (15th ACC Meeting), 2013

·   Hubei Province Youth Medal, 2013

·   NanKai University Lectureship on Organic Chemistry,2013

·   First-Class Natural Science Award of Hubei Province, 2012

·   Eli Lilly Scientific Excellence Award in Chemistry, 2011

·   Lectureship Award under the New Phase Asian Core Program on Cutting-Edge Organic Chemistry in Asia, Singapore, 2011

·   Lectureship Awardee of Asian International Symposium for Outstanding Young Scientists, 2011

·   Lectureship Award under the New Phase Asian Core Program on Cutting-Edge Organic Chemistry in Asia, Japan, 2011

·   National Science Fund for Distinguished Young Scholars, China, 2010

·   CAPA (Chinese-American Chemistry & Chemical Biology Professors Association) Distinguished Faculty Award, 2009

·   Chinese Chemistry SocietyJohn Wiley Young Chemist Award, 2008 

·   Royal Society Chemistry Journal Grant, 2008

·   Synthesis & Synlett  Journal Award, 2008

·   Wuxi Pharmtech Biological & Organic Creative Award, 2007

·   Luojia Scholarship Professor (Wuhan University), 2007

·   Outstanding Young Scientist of Hubei Province, 2006



Book Chapters


1)      Lei, A. W.; Jin, L. Q. Case Study of Mechanisms in Synthetic Reactions in Organic Chemistry – Breakthroughs and Perspectives, eds. Ding, K. L.; Dai, L.X. Wiley-VCH, Weinheim, 2012, August
2)      Lei, A. W.; Zhang, H. Transition Metal-Catalysed Direct Arylation of Unactivated Arenes with Aryl Halides in C-H and C-X Bond Functionalization: Transition Metal Mediation,Ed. Ribas, X. RSC, 2013

3)      He, C.; Lei, A. W. Application of Nontoxic Iron Salts in Oxidative C-C Coupling Reactions in Comprehensive Inorganic Chemistry II, eds. Reedijk, J. and Poeppelmeier, K., Vol 6. Oxford: Elsevier; 2013. p. 521-547.
4)   Lei, A. W.W.; Liu, W. Directed Aryl C-H Oxidations with Transition Metals. In: Molander and Paul Knochel (eds.), Comprehensive Organic Synthesis, 2nd edition, Vol 7, Oxford: Elsevier; 2014. PP. 313-346

5)      Lei, A. Shi, W. Liu, C. Liu, W. Zhang, H. He, C. Oxidative Cross-Coupling Reactions. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527680986.



Selective Publications

(1) Zeng, Li; Li, Haoran; Hu, Jingcheng; Zhang, Dongchao; Hu, Jiayu; Peng, Pan; Wang, Shenchun; Shi, Renyi; Peng, Jiaqi; Pao, Chih-Wen; Chen, Jeng-Lung; Lee, Jyh-Fu; Zhang, Heng; Chen, Yi-Hung; Lei, Aiwen. Electrochemical Oxidative Aminocarbonylation of Terminal Alkynes. Nat. Catal. 20203, 438-445.
(2) Niu, Linbin; Jiang, Chongyu; Liang, Yuwei; Liu, Dingdong; Bu, Faxiang; Shi, Renyi; Chen, Hong; Abhishek Dutta Chowdhury; Lei, Aiwen. Manganese-Catalyzed Oxidative Azidation of C(sp3)-H Bonds under Electrophotocatalytic Conditions. J. Am. Chem. Soc. 2020, DOI: org/10.1021/jacs.0c08437
(3) Hu, Xia; Nie, Lei; Zhang, Guoting; Aiwen Lei. Electrochemical Oxidative [4+2] Annulation for the π-Extension of Unfunctionalized Hetero-biaryl Compounds. Angew. Chem. Int. Ed. 2020, 59, 15238–15243.
(4) Song, Chunlan; Liu, Kun; Jiang Xu; Dong, Xin; Weng, Yue; Chiang, Chien-Wei; Lei, Aiwen. Dehydrogenative [4+2] Annulation between Indole Derivatives. Angew. Chem. Int. Ed. 202059, 7193 – 7197.
(5) Wang, Huamin; Liang, Kailun; Xiong, Wenpeng; Samanta, Supravat; Li, Wuqin; Lei, Aiwen. Electrochemical oxidation-induced etherification via C(sp3)─H/O─H cross-coupling. Sci. Adv. 2020, 6, eaaz0590.
(6) Liu, Kun; Song, Wenxu; Deng, Yuqi; Yang, Huiyue; Song, Chunlan; Abdelilah, Takfaoui; Wang, Shengchun; Cong, Hengjiang; Tang, Shan; Lei, Aiwen. Electrooxidation Enables Highly Regioselective Dearomative Annulation of Indole and Benzofuran Derivatives. Nat. Commun. 2020, 11, 3. DOI: org/10.1038/s41467-019-13829-4.
(7) Yuan, Yong; Lei, Aiwen. Is electrosynthesis always green and advantageous compared to traditional methods. Nat Commun202011, 802.
(8) Yuan, Yong; Zheng, Yongfu; Xu, Bizhen; Liao, Jiapeng; Bu, Faxiang; Wang, Shengchun; Hu,  Jian-Guo; Lei, Aiwen. Mn-Catalyzed Electrochemical Radical Cascade Cyclization towards the Synthesis of Benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-one Derivatives. ACS Catal2020, 10, 6676–6681.
(9) Duan, Zhengli; Zhang, Lin; Zhang, Wenxin; Lu, Lijun; Zeng, Li; Shi, Renyi; Lei , Aiwen. Palladium-Catalyzed Electro-oxidative C−H Amination toward the Synthesis of Pyrido[1,2‑a] benzimidazoles with Hydrogen Evolution. ACS Catal. 202010, 3828−3831.
(10) Wang, Huamin; Gao, Xinlong; Lv, Zongchao; Abdelilah, Takfaoui; Lei, Aiwen. Recent Advances in Oxidative R1-H/R2-H Cross-Coupling with Hydrogen Evolution via Photo-/Electrochemistry. Chem. Rev, 2019,119, 12, 6769–6787.
(11)Yuan, Yong; Lei, Aiwen. Electrochemical Oxidative Cross-Coupling with Hydrogen Evolution Reactions. Acc. Chem. Res. 2019, 52, 12, 3309–3324.
(12) Wang, Pan; Yang, Zhenlin; Wang, Ziwei; Xu, Chenyang; Huang, Lei; Wang, Shengchun; Zhang, Heng; Lei, Aiwen. Electrochemical Arylation of Electron-Deficient Arenes through Reductive Activation. Angew. Chem. Int. Ed. 201958, 15747 –15751.
(13) Song, Chunlan; Dong, Xin; Wang, Zhongjie; Liu, Kun; Chiang, Chien-Wei; Lei, Aiwen. Visible-Light-Induced [4+2] Annulation of Thiophenes and Alkynes to Construct Benzene Rings.
Angew. Chem. Int. Ed. 2019, 58, 12206–12210.
(14) Hu,Xia; Zhang, Guoting; Nie, Lei; Kong, Taige; Lei, Aiwen. Electrochemical oxidation induced intermolecular aromatic C-H imidation. Nat. Commun. 2019, 10, 5467. 
(15) Wang, Dan; Wang Pan; Wang, Shengchun; Chen Yi-Hung; Zhang, Heng; Lei, Aiwen. Direct Electrochemical Oxidation of Alcohols with Hydrogen Evolution in Continuous-flow Reactor. Nat. Commun. 2019, 10, 2796.
(16) Liu, Kun; Tang, Shan; Wu, Ting; Wang, Shengchun; Zou, Minzhu; Cong, Hengjiang; Lei,  Aiwen. Electrooxidative para-selective C–H/N–H cross-coupling with hydrogen evolution to synthesize triarylamine derivatives. Nat. Commun. 2019, 10, 639.
(17) Niu, Linbin; Liu, Jiamei; Liang, Xing-An; Wang Shengchun; Lei, Aiwen. Visible Light-Induced Direct α C–H Functionalization of Alcohols. Nat. Commun. 2019, 10, 467.
(18) Wang, Huamin; Li, Yongli; Lu, Qingquan; Yu, Mingming; Bai, Xudong; Wang, Shengchun Cong, Hengjiang; Zhang, Heng; Lei Aiwen. Oxidation-Induced β-Selective C-H Bond Functionalization: Thiolation and Selenation of N-Heterocycles. ACS Catal. 2019, 9, 3, 1888–1894.
(19) Tang, Shan; Liu, Yichang; Lei, Aiwen. Electrochemical Oxidative Cross-coupling with Hydrogen Evolution: A Green and Sustainable Way for Bond Formation. Chem. 2018, 4, 27-45
(20) Lu, Lijun; Pei, Xianglin; Mei, Yuan; Deng, Yi; Zhang, Heng; Zhang, Lina; Lei, Aiwen. Carbon Nanofibrous Microspheres Promote the Oxidative Double Carbonylation of Alkanes with CO. Chem. 2018, 4, 12, 2861-2871.
(21) Tang, Shan; Wang, Dan; Liu, Yichang; Zeng, Li; Lei, Aiwen. Cobalt-catalyzed electrooxidative C-H/N-H [4+2] annulation with ethylene or ethyne. Nature. Commun. 2018, 9, 798.
(22) Zhang Guoting; Lin, Yulin; Luo, Xu; Hu, Xia; Chen, Cong; Lei, Aiwen. Oxidative [4+2] annulation of styrenes with alkynes under external-oxidant-free conditons. Nat. Commun. 2018, 9, 1225.
(23) Tang, Shan; Zeng, Li; Lei, Aiwen. Oxidative R1-H/R2-H Cross-Coupling with Hydrogen Evolution. J. Am. Chem. Soc., 2018, 140, 13128-13135.
(24) Tang, Shan; Liu, Yichang; Gao, Xinlong; Wang, Pan; Huang, Pengfei; Lei, Aiwen. Multi-Metal-Catalyzed Oxidative Radical Alkynylation with Termianl Alkynes: A New Strategy for C(sp3)-C(sp) Bond Formation. J. Am. Chem. Soc. 2018, 140, 18, 6006–6013.
(25) Gao, Xinlong; Wang, Pan; Zeng, Li; Tang, Shan; Lei, Aiwen. Cobalt(II)-Catalyzed Electrooxidative C-H Amination of Arenes with Alkylamines. J. Am. Chem. Soc. 2018, 140, 4195-4199.
(26) Huang, Pengfei; Wang, Pan; Tang, Shan; Fu, Zhuangjiong; Lei, Aiwen. Electro-Oxidative S-H/S-H Cross-Coupling with Hydrogen Evolution: Facile Access to Unsymmetrical Disulfides. Angew. Chem. Int. Ed. 2018, 57, 8115-8119.
(27) Tang, Shan; Wang, Siyuan; Liu, Yichang; Cong, Hengjiang; Lei, Aiwen. Electrochemical Oxidative C-H Amination of Phenols: Access to Triarylamine Derivatives. Angew. Chem. Int. Ed. 2018, 130, 4827 –4831.
(28) Tang, Shan; Wang, Siyuan; Liu, Yichang; Cong, Hengjiang; Lei, Aiwen. Electrochemical oxidative C-H Amination of Phenols: Access to Triarylamine Derivatives. Angew. Chem. Int. Ed. 2018, 57, 4737 –4741.
(29) Hu, Xia; Zhang, Guoting; Bu, Faxiang; Lei, Aiwen. Selective Oxidative [4+2] Imine/Alkene Annulation with H2 Liberation Induced by Photo-Oxidation. Angew. Chem. Int. Ed. 2018, 57, 1286-1290.
(30) Yuan, Yong; Cao Yangmin; Lin, Yueping; Li, Yongli; Huang, Zhiliang; Lei, Aiwen. Electrochemical Oxidative Alkoxysulfonylation of Alkenes Using Sulfonyl Hydrazines and Alcohols with Hydrogen Evolution. ACS Catal. 2018, 8, 11, 10871–10875.
(31) Wang, Huamin; Li Yongli; Tang Zilu; Wang Shengchun; Heng, Zhang; Cong, Hengjiang; Lei, Aiwen. Z-Selective Addition of Diaryl Phosphine Oxides to Alkynes via Photoredox Catalysis. ACS Catal., 2018, 8, 11, 10599–10605.
(32) Yuan, Yong; Chen, Yixuan; Tang, Shan; Huang, Zhiliang; Lei, Aiwen. Electrochemical oxidative oxysulfenylation and aminosulfenylation of alkenes with hydrogen evolution. Sci. Adv.2018, 4, eaat5312.
(33) Zeng, Li; Li, Haoran; Tang, Shan; Gao, Xinlong; Deng, Yi; Zhang, Guoting; Pao, Chih-Wen; Chen, Jeng-Lung; Lee, Jyh-Fu; Lei, Aiwen. Cobalt-Catalyzed Electrochemical Oxidative C-H/N-H Carbonylation with Hydrogen Evolution. ACS Catal. 2018, 8, 5448-5453.
(34) Wu, Yong; Yi, Hong; Lei, Aiwen. Electrochemical Acceptorless Dehydrogenation of N-Heterocycles Utilizing TEMPO as Organo-Electrocatalyst. ACS Catal. 2018, 8, 1192-1196.
(35) Kirschner, Matthew S.; Ding, Wendu; Li, Yuxiu; Chapman, Craig T.; Lei, Aiwen; Lin, Xiao-Min; Chen, Lin X.; Schatz, George C.; Schaller, Richard D. Phonon-Driven Oscillatory Plasmonic Excitonic Nanomaterials. Nano. Lett. 2018, 18, 442-448.
(36) Song, Chunlan; Dong, Xin; Yi, Hong; Chiang, Chien-Wei; Lei, Aiwen. DDQ-Catalyzed Direct C(sp3)-H Amination of Alkylheteroarenes: Synthesis of Biheteroarenes under Aerobic and Metal-Free Conditions. ACS Catal. 2018, 8, 2195-2199.
(37) Liu, Kun; Tang, Shan; Huang, Pengfei; Lei, Aiwen. External oxidant-free electrooxidative [3 + 2] annulation between phenol and indole derivatives. Nature Commun. 20178, 775.

(38) Wang, Huaming; Lu, Qingquan; Chiang, Chien-Wei; Luo, Yi; Zhou, Jiufu; Wang, Guangyu; Lei, Aiwen. Markovnikov-Selective Radical Addition of S-Nucleophiles to Terminal Alkynes via Photoredox Process, Angew. Chem. Int. Ed. 2017, 129, 610-614.
(39) Yi, Hong; Niu, Linbin; Song, Chunlan; Li, Yiying; Dou, Bowen; Singh, Atul K; Lei, Aiwen.  Photocatalytic Dehydrogenative Cross-Coupling of Alkenes with Alcohols or Azoles without External Oxidant, Angew. Chem. Int. Ed. 2017, 56, 1120 –1124.
(40) Wang, Pan; Tang, Shan; Huang, Pengfei; Lei, Aiwen. Electrocatalytic Oxidant-Free Dehydrogenative C-H/S-H Cross Coupling, Angew. Chem. Int. Ed. 2017, 56, 3009-3013.
(41) Niu, Linbing; Yi, Hong; Wang, Shengchun; Liu, Tianyi; Liu, Jiamei; Lei, Aiwen. Photo-induced oxidant-free oxidative C–H/N–H cross-coupling between arenes and azoles, Nature Commun.2017, 8, DOI: 10.1038/ncomms14226.
(42) Yi, Hong; Yang, Dali; Xin, Jie; Qi, Xiaotian; Lan, Yu; Deng, Yi; Pao, Chih-Wen; Lee, Jyh-Fu; Lei, Aiwen. Unravelling the hidden link of lithium halides and application in the synthesis of organocuprates, Nature Commun.2017, 8, DOI: 10.1038/ncomms14794
(43) Yi, Hong; Zhang, Guoting; Wang, Huamin; Huang, Zhiyuan; Wang, Jue; Singh, Atul K.; Lei, Aiwen, Recent Advances in Radical C-H Activation/Radical Cross-Coupling. Chem. Rev. 2017117, 9016 – 9085.
(44) Crabtree, Robert H; Lei, Aiwen. Introduction: C-H Activation. Chem. Rev. 2017, 117, 8481 – 8482.
(45) Kirschner, Matthew S; Ding, Wendu; Li, Yuxiu; Chapman, Craig T; Lei Aiwen; Lin, Xiao-Min; Chen, Lin X; Schatz, George C; Schaller, Richard D. Phonon-Driven Oscillatory Plasmonic Excitonic Nanomaterials. Nano Lett. 2017, DOI: 10.1021/acs.nanolett.7b04354.
(46) Niu, Linbin; Liu, Jiamei; Yi, Hong; Wang, Shengchun; Liang, Xing-An; Singh, Atul K; Chiang, Chien-Wei; Lei, Aiwen. Visible-Light-Induced External Oxidant-Free Oxidative Phosphonylation of C(sp2)-H Bonds. ACS Catalysis20177, 7412 – 7416.
(47) Hu, Xia; Zhang,Guoting; Bu,Faxiang; Lei, Aiwen. Visible-Light-Mediated Anti-Markovnikov Hydration of Olefins. ACS Catal.2017, 7, 1432–1437.
(48) Wu, Jiwei; Zhou, Yi; Zhou, Yuchen; Chiang, Chien-Wei; Lei, Aiwen. Electro-Oxidative C(sp3)-H Amination of Azoles via Intermolecular Oxidative C(sp3)-H/N-H Cross-Coupling. ACS Catal. 20177, 8320-8323.
(49) Tang, Shan; Wang, Pan; Li, Haoran; Lei, Aiwen, Multimetallic Catalyzed Radical Oxidative C(sp3)–H/C(sp)–H Cross-Coupling between Unactivated Alkanes and Terminal Alkynes, Nat. Commun. 2016, 7, 11676.
(50) Wu. Qian; Luo, Yi; Lei, Aiwen; You, Jingsong, Aerobic Copper-Promoted Radical-Type Cleavage of Coordinated Cyanide Anion: Nitrogen Transfer to Aldehydes to Form Nitriles. J. Am. Chem. Soc. 2016138, 2885-2888.
(51) Zhang, Guoting; Hu, Xia; Chiang, Chien-Wei; Yi, Hong; Pei, Pengkun; Singh, Atul K.; Lei, Aiwen, Anti-Markovnikov Oxidation of β-Alkyl Styrenes with H2O as the Terminal Oxidant, J. Am. Chem. Soc. 2016, 138, 12037-12040.
(52) Wang, Huamin; Lu, Qingquan; Qian, Chaohang; Liu, Chao; Liu, Wei; Chen, Kai; Lei, Aiwen, Solvent-Enabled Radical Selectivities: Controlled Syntheses of Sulfoxides and Sulfides. Angew. Chem. Int. Ed. 2016, 55, 1094-1097.
(53) Li, Wu; Duan, Zhengli; Zhang, Xueye; Zhang, Heng; Wang, Mengfan; Jiang, Ru;  Zeng, Hongyao; Liu, Chao; Lei, Aiwen, From Anilines to Isatins: Oxidative Palladium-Catalyzed Double Carbonylation of C−H Bonds. Angew. Chem. Int. Ed. 201554, 1893-1896.
(54) Liu, Jianming; Zhang, Xin; Yi, Hong; Liu, Chao; Liu, Ren; Zhang, Heng; Zhuo, Kelei; Lei, Aiwen, Chloroacetate-Promoted Selective Oxidation of Heterobenzylic Methylenes under Copper Catalysis. Angew. Chem. Int. Ed. 201554, 1261-1265.
(55) Tang, Shan; Liu, Kun; Liu, Chao; Lei, Aiwen, Olefinic C–H Functionalization through Radical Alkenylation. Chem. Soc. Rev. 2015, 44, 1070-1082.
(56) Ke, Jie; Tang, Yuliang; Yi, Hong; Li, Yali; Cheng, Yongde; Liu, Chao; Lei, Aiwen, Copper-Catalyzed Radical/Radical C(sp3)-H/P-H Cross-Coupling: α-Phosphorylation of Aryl Ketone O-Acetyloximes. Angew. Chem. Int. Ed. 201554, 6604-6607.
(57) Zhang, Guoting; Liu, Chao; Yi, Hong; Meng, Qingyuan; Bian, Changliang; Chen, Hong; Jian, Jing-Xin; Wu, Li-Zhu; Lei, Aiwen, External Oxidant-Free Oxidative Cross-Coupling: A Photoredox Cobalt-Catalyzed Aromatic C-H Thiolation for Constructing C-S Bonds. J. Am. Chem. Soc. 2015137, 9273-9280.
(58) Tang, Shan; Zeng, Li; Liu, Yichang; Lei, Aiwen, Zinc-Catalyzed Dehydrogenative Cross-Coupling of Terminal Alkynes with Aldehydes: Access to Ynones. Angew. Chem. Int. Ed. 2015, 54, 15850-15853.
(59) Liu, Chao; Yuan, Jiwen; Gao, Meng; Tang, Shan; Li, Wu; Shi, Renyi; Lei, Aiwen, Oxidative Coupling between Two Hydrocarbons: An Update of Recent C-H Functionalizations. Chem. Rev. 2015115, 12138-12204.
(60) Wu, Kun; Huang, Zhiliang; Qi, Xiaotian; Li, Yingzi; Zhang, Guanghui; Liu, Chao; Yi, Hong; Meng, Lingkui; Bunel, Emilio E.; Miller, Jeffrey T.; Pao, Chih-Wen; Lee, Jyh-Fu; Lan, Yu; Lei, Aiwen, Copper-Catalyzed Aerobic Oxidative Coupling: From Ketone and Diamine to Pyrazine. Sci. Adv. 2015, 1, e1500656.
(61) Zhang, G. H.; Yi, H.; Zhang, G. T.; Deng, Y.; Bai, R. P.; Zhang, H.; Miller, J. T.; Kropf, A.J.; Bunel, E.E.; Lei, A. W., Direct Observation of Reduction of Cu(II) to Cu(I) by Terminal Alkynes. J. Am. Chem. Soc. 2014, 136, 924-926.
(62) Liu, J.; Liu, Q.; Yi, H.; Qin, C.; Bai, R. P.; Qi, X. T.; Lan, Y.; Lei, A. W., Visible Light Mediated Decarboxylation / Oxidative Amidation of α-Keto Acids with Amines under Mild Conditions Using O2. Angew Chem Int Ed. 2014, 53, 502.
(63)Li, W.; Liu, C.; Zhang, H.; Ye, K.Y.; Zhang, G. H.; Zhang, W. Z.; Duan, Z. L.; You, S. L.; Lei, A. W., Palladium-Catalyzed Oxidative Carbonylation of N-allylamines for the synthesis of â-lactams. Angew Chem Int Ed. 2014, 53, 2443.
(64)Wang, L.; Wang, Y. X.; Liu, C.; Lei, A. W., CO/C-H as the Acylative Reagent: A Palladium-Catalyzed Aerobic Oxidative Carbonylative Esterfication of Alcohols. Angew Chem Int Ed. 2014, 53, 5657.
(65) Bai, R.P.; Zhang, G.Y.; Yi, H.; Huang, Z.L.; Qi, X.T.; Liu, C.; Miller, J. T; Kropf, A. J.; Bunel E. E.; Lan, Yu.; Lei, A.W. Cu(II)/Cu(I)-Synergistic Cooperation to Lead the Alkyne C-H Activation. J. Am. Chem. Soc. 2014136, 16760–16763.
(66) Liu, C.; Liu, D.; Lei, A. W., Recent Advance of Transition-Metal Catalyzed Radical Oxidative Cross-Couplings. Acc. Chem. Res. 2014, 47, 3459−3470.
(67) He, C.; Zhang, G. H.; Ke, J.; Zhang, H.; Miller, J. T.; Kropf, A. J.; Lei, A. W., Labile Cu(I)-Catalyst/Spectator Cu(II)-Species in Copper-Catalyzed C-C Coupling Reaction: Operando IR, In situ XANES/EXAFS Evidence and Kinetic Investigations. J. Am. Chem. Soc. 2013135, 488.
(68) Lu, Q. Q.; Zhang, J.; Zhao, G. L.; Qi, Y.; Wang, H. M.; Lei, A. W., Dioxygen-Triggered Oxidative Radical Reaction: Direct Aerobic Difunctionalization of Terminal Alkynes towards β-Keto Sulfones. J. Am. Chem. Soc.  2013135, 11481.
(69) Muto, K.; Yamaguchi, J.; Lei, A. W.; Itami, K., Isolation, Structure, and Reactivity of an Arylnickel(II) Pivalate Complex in Catalytic C-H/C-O Biaryl Coupling. J. Am. Chem. Soc.  2013135, 16384.
(70) He, C.; Ke, J.; Xu, H.; Lei, A. W., Insights toward the Symbiotic Catalysis Sonogashira Coupling Reaction: Quantitative Kinetic Investigation of Transmetalation.  Angew Chem Int Edit.  201352, 1527.
(71) Wang, J.; Liu, C.; Yuan, J. W.; Lei, A. W., Copper-Catalyzed Oxidative Coupling of Alkenes with Aldehydes: Direct Access to α, β-unsaturated Ketones. Angew Chem Int Edit. 201352, 2256.
(72) Liu, D.; Liu, C.; Li, H.; Lei, A. W., Direct Funtionalization of Tetrahydrofuran and 1,4-Dioxane: A Nickel-Catalyzed Oxidative Csp3-H Arylation. Angew Chem Int Ed. 201352, 4453.
(73) Gao, M.; He, C.; Chen, H. Y.; Bai, R. P.; Cheng, B.; Lei, A. W., Synthesis of Pyrrole by Click Reaction: Silver-Catalyzed Cycloaddition of Terminal Alkynes with isocyanides. Angew Chem Int Edit. 201352, 6958.
(74) Huang, Z. L.; Jin, L. Q.; Feng, Y.; Peng, P.; Yi, H.; Lei, A. W., Iron-Catalyzed Oxidative Radical Cross-Coupling/Cyclization between Phenol and Olefin. Angew Chem Int Edit. 201352, 7151.
(75) Lu, Q. Q.; Zhang, J.; Wei, F. L.; Qi, Y.; Wang, H. M.; Liu, Z. L.; Lei, A. W. Dioxygen Activation by Sulfinic Acids: Direct Oxysulfonylation of Alkenes Leading to Secondary and Tertiary β-Hydroxysulfones. Angew Chem Int Ed. 201352, 7156.
(76) Meng, L. K.; Zhang, G. H.; Liu, C.; Wu, K.; Lei, A. W. Trifluoromethanesulfonic Acid Catalyzed Synergetic Oxidative / [3+2] Cyclization of Quinones with Olefins. Angew Chem Int Edit. 201352, 10195-10198.
(77) Shi, R. Y.; Zhang, H.; Lu, L. J.; Chen, B. R.; Sha, Y. C.; Liu, C.; Lei, A. W. Palladium / Copper-Catalyzed Oxidative C-H Alkenylation/N-Dealkylative Carbonylation of Tertiary Anilines. Angew Chem Int Edit. 201352, 10582.
(78) Guo, M.; Dong, H.; Li, J.; Cheng, B.; Huang, Y. Q.; Feng, Y. Q.; Lei, A. W. Spectroscopic Observation of Iodosylarene Metalloporphyrin Adducts and Manganese(V)-Oxo Porphyrin Species in a Cytochrome P450 Analogue. Nat commun. 2012, 3, 1190.
(79) He, C.; Guo, S.; Ke, J.; Hao, J.; Xu, H.; Chen, H. Y.; Lei, A. W. Silver-Mediated Oxidative C-H/C-H Functionalization: A Strategy To Construct Polysubstituted Furans. J. Am. Chem. Soc. 2012, 134, 5766.
(80) Zhang, H.; Shi, R. Y.; Ding, A. X.; Lu, L. J.; Chen, B. R.; Lei, A. W. Transition-metal-free Alkoxycarbonylation of Aryl Halides. Angew Chem Int Edit. 2012, 51, 12542.
(81) Weng, Y.; Cheng, B.; He, C.; Lei, A. W. Rational Design of Pd-Catalyzed Csp-Csp Cross-Coupling Reaction Inspired by Kinetic Studies. Angew Chem Int Edit. 2012, 51, 9547.
(82) Liu, C.; Tang, S.; Zheng, L.; Liu, D.; Zhang, H.; Lei, A. W. Covalently Bound Benzyl Ligand Promotes Selective Palladium-Catalyzed Oxidative Esterification of Aldehydes with Alcohols. Angew Chem Int Edit. 2012, 51, 5662.
(83) Zhang, H.; Shi, R. Y.; Gan, P.; Liu, C.; Ding, A. X.; Wang, Q. Y.; Lei, A. W. Palladium-Catalyzed Oxidative Double C-H Functionalization/Carbonylation for the Synthesis of Xanthones. Angew Chem Int Edit. 2012, 51, 5204.
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