Position:Home > Aiwen Lei

Aiwen Lei

 Prof. Aiwen Lei  
College of Chemistry and Molecular Sciences
  The Institute for Advanced Studies, Vice President
  Wuhan University, Wuhan, 430072 (P. R. China)
  Fax: (+86)27-6875-4672
  E-mail: aiwenlei@whu.edu.cn

  Prof. Aiwen Lei (08/1973)
  ORCID 0000-0001-8417-3061
  ResearcherID G-8033-2015
  Scopus Author ID 7003632949

  Prof. Lei’s author profile published on Angew.Chem.Int.Ed., 2011, 12136.



  Ph. D., Organic Chemistry, July, 2000, Shanghai Institute of Organic Chemistry, Chinese Academy of Science (CAS), China Supervisor – Prof. Xiyan Lu

  B.S., Chemistry Education, July, 1995, Huaibei Normal University, Huaibei, AnHui Province, P. R. China

Research Experience

·        2005.3- Professor of Wuhan University

·        2003.8-2005.3, Research Associate, Department of Chemistry, Stanford University, with Professor James, P. Collman

·        2000.8-2003.8 Postdoctoral Fellow, Department of Chemistry, the Pennsylvania State University, with Professor Xumu Zhang

·        1995.9-2000.7 Graduate Studies, Shanghai Institute of Organic Chemistry, CAS, China (SIOC)


Selected Awards

·   The Third Batch of National Million Plan Leader, 2017

·   Overseas Chinese (Innovative Talents) Contribution Award, 2016

·   The National Youth Science and Technology Innovation Talents, 2015

·   The Roche Chinese Young Investigator Award, 2015

·   Fellow of the Royal Society of Chemistry, FRSC, 2015

·   Yangtse River Scholar Distinguished Professor, 2014

·   Second-Class Natural Science Award of Liaoning Province, 2014

·   Overseas Chinese (Innovative Talents) Contribution Award, 2014

·   Youth Chemist Award of the Chinese Chemical SocietyPhysical Organic Chemistry, 201

·   Committee of the Chinese Physical Organic Chemical Society, 2014

·   Chinese Chemistry SocietyRoyal Society of Chemistry Young Chemist Award, 2014

·   Guest Professor, University of Münster, 2013

·   Asian Rising Stars (15th ACC Meeting), 2013

·   Hubei Province Youth Medal, 2013

·   NanKai University Lectureship on Organic Chemistry,2013

·   First-Class Natural Science Award of Hubei Province, 2012

·   Eli Lilly Scientific Excellence Award in Chemistry, 2011

·   Lectureship Award under the New Phase Asian Core Program on Cutting-Edge Organic Chemistry in Asia, Singapore, 2011

·   Lectureship Awardee of Asian International Symposium for Outstanding Young Scientists, 2011

·   Lectureship Award under the New Phase Asian Core Program on Cutting-Edge Organic Chemistry in Asia, Japan, 2011

·   National Science Fund for Distinguished Young Scholars, China, 2010

·   CAPA (Chinese-American Chemistry & Chemical Biology Professors Association) Distinguished Faculty Award, 2009

·   Chinese Chemistry SocietyJohn Wiley Young Chemist Award, 2008 

·   Royal Society Chemistry Journal Grant, 2008

·   Synthesis & Synlett  Journal Award, 2008

·   Wuxi Pharmtech Biological & Organic Creative Award, 2007

·   Luojia Scholarship Professor (Wuhan University), 2007

·   Outstanding Young Scientist of Hubei Province, 2006



Book Chapters


1)      Lei, A. W.; Jin, L. Q. Case Study of Mechanisms in Synthetic Reactions in Organic Chemistry – Breakthroughs and Perspectives, eds. Ding, K. L.; Dai, L.X. Wiley-VCH, Weinheim, 2012, August
2)      Lei, A. W.; Zhang, H. Transition Metal-Catalysed Direct Arylation of Unactivated Arenes with Aryl Halides in C-H and C-X Bond Functionalization: Transition Metal Mediation,Ed. Ribas, X. RSC, 2013

3)      He, C.; Lei, A. W. Application of Nontoxic Iron Salts in Oxidative C-C Coupling Reactions in Comprehensive Inorganic Chemistry II, eds. Reedijk, J. and Poeppelmeier, K., Vol 6. Oxford: Elsevier; 2013. p. 521-547.
4)   Lei, A. W.W.; Liu, W. Directed Aryl C-H Oxidations with Transition Metals. In: Molander and Paul Knochel (eds.), Comprehensive Organic Synthesis, 2nd edition, Vol 7, Oxford: Elsevier; 2014. PP. 313-346

5)      Lei, A. Shi, W. Liu, C. Liu, W. Zhang, H. He, C. Oxidative Cross-Coupling Reactions. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527680986.



Selective Publications


1)      Xia Hu, Guoting Zhang, Faxiang Bu and Aiwen Lei. Selective Oxidative [4+2] Imine/Alkene Annulation with H2 Liberation Induced by Photo-Oxidation. Angew. Chem. Int. Ed. 2018, DOI: 10.1002/anie.201711359

2)      Kun Liu, Shan Tang, Pengfei Huang, Aiwen Lei. External oxidant-free electrooxidative [3 + 2] annulation between phenol and indole derivatives. Nature Commun. 2017, 8, 775.
3)      Shan Tang, Yichang Liu and Aiwen Lei. Electrochemical Oxidative Cross-Coupling with Hydrogen Evolution: A Green and Sustainable Way for Bond Formation. Chem 2018, 4, DOI: 10.1016/j.chempr.2017.10.001
4)      Wang, H. M.; Lu, Q. Q.; Chiang, C. W.; Luo, Y.; Zhou, J. F.; Wang, G. Y.; and Lei, A. W.; Markovnikov-Selective Radical Addition of S-Nucleophiles to Terminal Alkynes via Photoredox Process, Angew. Chem. Int. Ed. 2017, 129, 610-614

5)      Yi, H.; Niu, L. B.; Song, C. L.; Li, Y. Y.; Dou, B. W.; Singh, A. K.; Lei, A. W.;  Photocatalytic Dehydrogenative Cross-Coupling of Alkenes with Alcohols or Azoles without External Oxidant, Angew. Chem. Int. Ed. 2017, 56, 1120 –1124.

6)      Wang, P.; Tang, S.; Huang, P. F.; Lei, A. W.; Electrocatalytic Oxidant-Free Dehydrogenative C-H/S-H Cross Coupling, Angew. Chem. Int. Ed. 2017, 56, 3009-3013.

7)      Niu, L. B.; Yi, H.; Wang, S. C.; Liu, T. Y.; Liu, J. M.; Lei, A. W.; Photo-induced oxidant-free oxidative C–H/N–H cross-coupling between arenes and azoles, Nature Commun., 2017, 8, DOI: 10.1038/ncomms14226.

8)      Yi, H.; Yang, D. L.; Xin, J.; Qi, X. T.; Lan, Y.; Deng, Y.; Pao, C. W.; Lee, J. F.; Lei, A. W.; Unravelling the hidden link of lithium halides and application in the synthesis of organocuprates, Nature Commun., 2017, 8, DOI: 10.1038/ncomms14794

9)      Yi, Hong; Zhang, Guoting; Wang, Huamin; Huang, Zhiyuan; Wang, Jue; Singh, Atul K.; Lei, Aiwen, Recent Advances in Radical C-H Activation/Radical Cross-Coupling. Chem. Rev. 2017, 117, 9016 – 9085.

10)   Crabtree, Robert H.; Lei, Aiwen, Introduction: C-H Activation. Chem. Rev. 2017, 117, 8481 – 8482.

11)   Matthew S. Kirschner, Wendu Ding, Yuxiu Li, Craig T. Chapman, Aiwen Lei, Xiao-Min Lin, Lin X. Chen, George C. Schatz, and Richard D. Schaller. Phonon-Driven Oscillatory Plasmonic Excitonic Nanomaterials. Nano Lett. 2017, DOI: 10.1021/acs.nanolett.7b04354.

12)   Wang, H. M.; Lu, Q. Q.; Qian, C. H.; Liu, C.; Liu, W.; Chen, K.; Lei, A. W., Solvent Enabled Radical Selectivities: Controlled Syntheses of Sulfoxides and Sulfides. Angew. Chem. Int. Ed., 2016, 55, 1094-1097.

13)   Wu. Q.; Luo, Y.; Lei, A. W.; You, J. S., Aerobic Copper-Promoted Radical-Type Cleavage of Coordinated Cyanide Anion: Nitrogen Transfer to Aldehydes to Form Nitriles. J. Am. Chem. Soc.2016138 (9), 2885–2888.

14)   Tang, S.; Wang, P.; Li, H.; Lei, A. W., Multimetallic catalysed radical oxidative C(sp3)–H/C(sp)–H cross-coupling between unactivated alkanes and terminal alkynes, Nature communications 2016, 7, 11676, DOI:10.1038/ncomms11676

15)   Zhang, G. T.; Hu, X.; Chiang, C. W.; Yi, H.; Pei, P. K.; Singh, K, Atul.; Lei, A. W.,  Anti-Markovnikov Oxidation of β-Alkyl Styrenes with H2O as the Terminal Oxidant, J. Am. Chem. Soc., 2016, 138, 12037−12040

16)   Wu Li, Zhengli Duan, Xueye Zhang, Heng Zhang, Mengfan Wang, Ru Jiang, Hongyao Zeng, Chao Liu and Aiwen Lei, From Anilines to Isatins: Palladium-Catalyzed Oxidative C−H Double Carbonylation. Angew. Chem. Int. Ed. 2015, 54, 1893-1896.

17)   Jianming Liu, Xin Zhang, Hong Yi, Chao Liu, Ren Liu, Heng Zhang, Kelei Zhuo, and Aiwen Lei. Chloroacetate-Promoted Selective Oxidation of Heterobenzylic Methylenes under Copper Catalysis. Angew. Chem. Int. Ed. 2015, 54, 1261–1265.

18)   Shan Tang, Kun Liu, Chao Liu, and Aiwen Lei, Olefinic C-H functionalization through radical alkenylation. Chem. Soc. Rev. 2015, 44(5), 1070-1082.

19)   Ke, J.; Tang, Y. L.; Yi, H.; Li, Y. L.; Cheng, Y. D.; Liu, C.; Lei, A. W., Copper-Catalyzed Radical/Radical C(sp3)-H/P-H Cross-Coupling: α-Phosphorylation of Aryl Ketone O-Acetyloximes. Angew. Chem. Int. Ed., 2015, 54, 6604-6607.

20)   Zhang, G. T.; Liu, C.; Yi, H.; Meng, Q. Y.; Bian, C. L.; Chen, H.; Jian, J. X.; Wu, L. Z.; Lei, A. W., External Oxidant-Free Oxidative Cross-Coupling: A Photoredox Cobalt-Catalyzed Aromatic C-H Thiolation for Constructing C-S Bonds. J. Am. Chem. Soc. 2015, 137, 9273–9280.

21)   Tang, S.; Zeng, L.; Liu, Y. C.; Lei, A. W., Zinc-Catalyzed Dehydrogenative Cross-Coupling of Terminal Alkynes with Aldehydes: A Simple Access to Ynones. Angew. Chem. Int. Ed. 2015, 54, 15850 –15853.

22)   Liu, C.; Yuan, J. W.; Gao, M.; Tang, S.; Li, W.; Shi, R. Y.; Lei, A. W., Oxidative Coupling between Two Hydrocarbons: An Update of Recent C-H Functionalizations. Chem. Rev.2015115 (22), 12138–12204.

23)   Wu, K.; Huang, Z. L.; Qi, X. T.; Li, Y. Z.; Zhang, G. H.; Liu, C.; Yi, H.; Meng, L. K.; Bunel, E. E.; Miller, J. T.; Pao, C. W.; Lee, J. F.; Lan, Y.; Lei, A. W., Copper-Catalyzed Aerobic Oxidative Coupling: From Ketone and Diamine to Pyrazine. Sci. Adv. 2015, Vol. 1, no. 9, e1500656. DOI: 10.1126/sciadv.1500656.

24)   Zhang, G.H.; Yi, H.; Zhang, G.T.; Deng, Y.; Bai, R.P.; Zhang, H.; Miller, J.T.; Kropf, A.J.; Bunel, E.E.; Lei, A. W., Direct Observation of Reduction of Cu(II) to Cu(I) by Terminal Alkynes. J Am Chem Soc 2014, 136, 924-926 

25)   Liu, J.; Liu, Q.; Yi, H.; Qin, C.; Bai, R. P.; Qi, X. T.; Lan, Y.; Lei, A. W., Visible Light Mediated Decarboxylation / Oxidative Amidation of α-Keto Acids with Amines under Mild Conditions Using O2. Angew Chem Int Ed 2014, 53, 502

26)   Li, W.; Liu, C.; Zhang, H.; Ye, K.Y.; Zhang, G.H.; Zhang, W.Z.; Duan, Z.L.; You, S.L.; Lei, A. W., Palladium-Catalyzed Oxidative Carbonylation  of N-allylamines for the synthesis of â-lactams. Angew Chem Int Ed 2014, 53, 2443

27)   Wang, L.; Wang, Y.X.; Liu, C.; Lei, A. W., CO/C-H as the Acylative Reagent: A Palladium-Catalyzed Aerobic Oxidative Carbonylative Esterfication of Alcohols. Angew Chem Int Ed 2014, 53, 5657

28)   Ruopeng Bai, Guanghui Zhang, Hong Yi, Zhiliang Huang, Xiaotian Qi, Chao Liu, Jeffrey T Miller, Arthur Jeremy Kropf, Emilio E Bunel, Yu Lan, and Aiwen Lei. Cu(II)/Cu(I)-Synergistic Cooperation to Lead the Alkyne C-H Activation. J. Am. Chem. Soc., 2014, 136, 16760–16763.

29)   Liu, C.; Liu, D.; Lei, A. W., Recent Advance of Transition-Metal Catalyzed Radical Oxidative Cross-Couplings. Acc. Chem. Res. 2014, 47, 3459−3470.

30)   He, C.; Zhang, G. H.; Ke, J.; Zhang, H.; Miller, J. T.; Kropf, A. J.; Lei, A. W., Labile Cu(I)-Catalyst/Spectator Cu(II)-Species in Copper-Catalyzed C-C Coupling Reaction: Operando IR, In situ XANES/EXAFS Evidence and Kinetic Investigations. J Am Chem Soc 2013, 135, 488

31)   Lu, Q. Q.; Zhang, J.; Zhao, G. L.; Qi, Y.; Wang, H. M.; Lei, A. W., Dioxygen-Triggered Oxidative Radical Reaction: Direct Aerobic Difunctionalization of Terminal Alkynes towards β-Keto Sulfones. J Am Chem Soc  2013, 135, 11481

32)   Muto, K.; Yamaguchi, J.; Lei, A. W.; Itami, K., Isolation, Structure, and Reactivity of an Arylnickel(II) Pivalate Complex in Catalytic C-H/C-O Biaryl Coupling. J Am Chem Soc  2013, 135, 16384

33)   He, C.; Ke, J.; Xu, H.; Lei, A. W., Insights toward the Symbiotic Catalysis Sonogashira Coupling Reaction: Quantitative Kinetic Investigation of Transmetalation.  Angew Chem Int Edit  2013, 52, 1527

34)   Wang, J.; Liu, C.; Yuan, J. W.; Lei, A. W., Copper-Catalyzed Oxidative Coupling of Alkenes with Aldehydes: Direct Access to α, β-unsaturated Ketones. Angew Chem Int Edit 2013, 52, 2256

35)   Liu, D.; Liu, C.; Li, H.; Lei, A. W., Direct Funtionalization of Tetrahydrofuran and 1,4-Dioxane: A Nickel-Catalyzed Oxidative Csp3-H Arylation. Angew Chem Int Ed 2013, 52, 4453

36)   Gao, M.; He, C.; Chen, H. Y.; Bai, R. P.; Cheng, B.; Lei, A. W., Synthesis of Pyrrole by Click Reaction: Silver-Catalyzed Cycloaddition of Terminal Alkynes with isocyanides. Angew Chem Int Edit 2013, 52, 6958

37)   Huang, Z. L.; Jin, L. Q.; Feng, Y.; Peng, P.; Yi, H.; Lei, A. W., Iron-Catalyzed Oxidative Radical Cross-Coupling/Cyclization between Phenol and Olefin. Angew Chem Int Edit 2013, 52, 7151