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Aiwen Lei

 Prof. Aiwen Lei  
College of Chemistry and Molecular Sciences
  The Institute for Advanced Studies
  Wuhan University, Wuhan, 430072 (P. R. China)
  Fax: (+86)27-6875-4672
  E-mail: aiwenlei@whu.edu.cn

  Prof. Aiwen Lei (08/1973)
  ORCID 0000-0001-8417-3061
  ResearcherID G-8033-2015
  Scopus Author ID 7003632949

  Prof. Lei’s author profile published on Angew.Chem.Int.Ed., 2011, 12136.

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Education

  Ph. D., Organic Chemistry, July, 2000, Shanghai Institute of Organic Chemistry, Chinese Academy of Science (CAS), China Supervisor – Prof. Xiyan Lu

  B.S., Chemistry Education, July, 1995, Huaibei Normal University, Huaibei, AnHui Province, P. R. China
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Research Experience

·        2005.3- Professor of Wuhan University

·        2003.8-2005.3, Research Associate, Department of Chemistry, Stanford University, with Professor James, P. Collman

·        2000.8-2003.8 Postdoctoral Fellow, Department of Chemistry, the Pennsylvania State University, with Professor Xumu Zhang

·        1995.9-2000.7 Graduate Studies, Shanghai Institute of Organic Chemistry, CAS, China (SIOC)

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Selected Awards

·   The Third Batch of National Million Plan Leader, 2017

·   Overseas Chinese (Innovative Talents) Contribution Award, 2016

·   The National Youth Science and Technology Innovation Talents, 2015

·   The Roche Chinese Young Investigator Award, 2015

·   Fellow of the Royal Society of Chemistry, FRSC, 2015 

·   Second-Class Natural Science Award of Liaoning Province, 2014

·   Overseas Chinese (Innovative Talents) Contribution Award, 2014

·   Youth Chemist Award of the Chinese Chemical SocietyPhysical Organic Chemistry, 201

·   Committee of the Chinese Physical Organic Chemical Society, 2014

·   Chinese Chemistry SocietyRoyal Society of Chemistry Young Chemist Award, 2014

·   Guest Professor, University of Münster, 2013

·   Asian Rising Stars (15th ACC Meeting), 2013

·   Hubei Province Youth Medal, 2013

·   NanKai University Lectureship on Organic Chemistry,2013

·   First-Class Natural Science Award of Hubei Province, 2012

·   Eli Lilly Scientific Excellence Award in Chemistry, 2011

·   Lectureship Award under the New Phase Asian Core Program on Cutting-Edge Organic Chemistry in Asia, Singapore, 2011

·   Lectureship Awardee of Asian International Symposium for Outstanding Young Scientists, 2011

·   Lectureship Award under the New Phase Asian Core Program on Cutting-Edge Organic Chemistry in Asia, Japan, 2011

·   National Science Fund for Distinguished Young Scholars, China, 2010

·   CAPA (Chinese-American Chemistry & Chemical Biology Professors Association) Distinguished Faculty Award, 2009

·   Chinese Chemistry SocietyJohn Wiley Young Chemist Award, 2008 

·   Royal Society Chemistry Journal Grant, 2008

·   Synthesis & Synlett  Journal Award, 2008

·   Wuxi Pharmtech Biological & Organic Creative Award, 2007

·   Luojia Scholarship Professor (Wuhan University), 2007

·   Outstanding Young Scientist of Hubei Province, 2006

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Book Chapters

 

1)      Lei, A. W.; Jin, L. Q. Case Study of Mechanisms in Synthetic Reactions in Organic Chemistry – Breakthroughs and Perspectives, eds. Ding, K. L.; Dai, L.X. Wiley-VCH, Weinheim, 2012, August
2)      Lei, A. W.; Zhang, H. Transition Metal-Catalysed Direct Arylation of Unactivated Arenes with Aryl Halides in C-H and C-X Bond Functionalization: Transition Metal Mediation,Ed. Ribas, X. RSC, 2013

3)      He, C.; Lei, A. W. Application of Nontoxic Iron Salts in Oxidative C-C Coupling Reactions in Comprehensive Inorganic Chemistry II, eds. Reedijk, J. and Poeppelmeier, K., Vol 6. Oxford: Elsevier; 2013. p. 521-547.
 
4)   Lei, A. W.W.; Liu, W. Directed Aryl C-H Oxidations with Transition Metals. In: Molander and Paul Knochel (eds.), Comprehensive Organic Synthesis, 2nd edition, Vol 7, Oxford: Elsevier; 2014. PP. 313-346

5)      Lei, A. Shi, W. Liu, C. Liu, W. Zhang, H. He, C. Oxidative Cross-Coupling Reactions. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527680986.

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Selective Publications


(1) Zeng, Li; Li, Haoran; Hu, Jingcheng; Zhang, Dongchao; Hu, Jiayu; Peng, Pan; Wang, Shenchun; Shi, Renyi; Peng, Jiaqi; Pao, Chih-Wen; Chen, Jeng-Lung; Lee, Jyh-Fu; Zhang, Heng; Chen, Yi-Hung; Lei, Aiwen. Electrochemical Oxidative Aminocarbonylation of Terminal Alkynes. Nat. Catal. 20203, 438-445.
 
(2) Niu, Linbin; Jiang, Chongyu; Liang, Yuwei; Liu, Dingdong; Bu, Faxiang; Shi, Renyi; Chen, Hong; Abhishek Dutta Chowdhury; Lei, Aiwen. Manganese-Catalyzed Oxidative Azidation of C(sp3)-H Bonds under Electrophotocatalytic Conditions. J. Am. Chem. Soc. 2020, DOI: org/10.1021/jacs.0c08437
 
(3) Hu, Xia; Nie, Lei; Zhang, Guoting; Aiwen Lei. Electrochemical Oxidative [4+2] Annulation for the π-Extension of Unfunctionalized Hetero-biaryl Compounds. Angew. Chem. Int. Ed. 2020, 59, 15238–15243.
 
(4) Song, Chunlan; Liu, Kun; Jiang Xu; Dong, Xin; Weng, Yue; Chiang, Chien-Wei; Lei, Aiwen. Dehydrogenative [4+2] Annulation between Indole Derivatives. Angew. Chem. Int. Ed. 202059, 7193 – 7197.
 
(5) Wang, Huamin; Liang, Kailun; Xiong, Wenpeng; Samanta, Supravat; Li, Wuqin; Lei, Aiwen. Electrochemical oxidation-induced etherification via C(sp3)─H/O─H cross-coupling. Sci. Adv. 2020, 6, eaaz0590.
 
(6) Liu, Kun; Song, Wenxu; Deng, Yuqi; Yang, Huiyue; Song, Chunlan; Abdelilah, Takfaoui; Wang, Shengchun; Cong, Hengjiang; Tang, Shan; Lei, Aiwen. Electrooxidation Enables Highly Regioselective Dearomative Annulation of Indole and Benzofuran Derivatives. Nat. Commun. 2020, 11, 3. DOI: org/10.1038/s41467-019-13829-4.
 
(7) Yuan, Yong; Lei, Aiwen. Is electrosynthesis always green and advantageous compared to traditional methods. Nat Commun202011, 802.
 
(8) Yuan, Yong; Zheng, Yongfu; Xu, Bizhen; Liao, Jiapeng; Bu, Faxiang; Wang, Shengchun; Hu,  Jian-Guo; Lei, Aiwen. Mn-Catalyzed Electrochemical Radical Cascade Cyclization towards the Synthesis of Benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-one Derivatives. ACS Catal2020, 10, 6676–6681.
 
(9) Duan, Zhengli; Zhang, Lin; Zhang, Wenxin; Lu, Lijun; Zeng, Li; Shi, Renyi; Lei , Aiwen. Palladium-Catalyzed Electro-oxidative C−H Amination toward the Synthesis of Pyrido[1,2‑a] benzimidazoles with Hydrogen Evolution. ACS Catal. 202010, 3828−3831.
 
(10) Wang, Huamin; Gao, Xinlong; Lv, Zongchao; Abdelilah, Takfaoui; Lei, Aiwen. Recent Advances in Oxidative R1-H/R2-H Cross-Coupling with Hydrogen Evolution via Photo-/Electrochemistry. Chem. Rev, 2019,119, 12, 6769–6787.
 
(11)Yuan, Yong; Lei, Aiwen. Electrochemical Oxidative Cross-Coupling with Hydrogen Evolution Reactions. Acc. Chem. Res. 2019, 52, 12, 3309–3324.
 
(12) Wang, Pan; Yang, Zhenlin; Wang, Ziwei; Xu, Chenyang; Huang, Lei; Wang, Shengchun; Zhang, Heng; Lei, Aiwen. Electrochemical Arylation of Electron-Deficient Arenes through Reductive Activation. Angew. Chem. Int. Ed. 201958, 15747 –15751.
(13) Song, Chunlan; Dong, Xin; Wang, Zhongjie; Liu, Kun; Chiang, Chien-Wei; Lei, Aiwen. Visible-Light-Induced [4+2] Annulation of Thiophenes and Alkynes to Construct Benzene Rings.
Angew. Chem. Int. Ed. 2019, 58, 12206–12210.
 
(14) Hu,Xia; Zhang, Guoting; Nie, Lei; Kong, Taige; Lei, Aiwen. Electrochemical oxidation induced intermolecular aromatic C-H imidation. Nat. Commun. 2019, 10, 5467. 
 
(15) Wang, Dan; Wang Pan; Wang, Shengchun; Chen Yi-Hung; Zhang, Heng; Lei, Aiwen. Direct Electrochemical Oxidation of Alcohols with Hydrogen Evolution in Continuous-flow Reactor. Nat. Commun. 2019, 10, 2796.
 
(16) Liu, Kun; Tang, Shan; Wu, Ting; Wang, Shengchun; Zou, Minzhu; Cong, Hengjiang; Lei,  Aiwen. Electrooxidative para-selective C–H/N–H cross-coupling with hydrogen evolution to synthesize triarylamine derivatives. Nat. Commun. 2019, 10, 639.
 
(17) Niu, Linbin; Liu, Jiamei; Liang, Xing-An; Wang Shengchun; Lei, Aiwen. Visible Light-Induced Direct α C–H Functionalization of Alcohols. Nat. Commun. 2019, 10, 467.
 
(18) Wang, Huamin; Li, Yongli; Lu, Qingquan; Yu, Mingming; Bai, Xudong; Wang, Shengchun Cong, Hengjiang; Zhang, Heng; Lei Aiwen. Oxidation-Induced β-Selective C-H Bond Functionalization: Thiolation and Selenation of N-Heterocycles. ACS Catal. 2019, 9, 3, 1888–1894.
 
(19) Tang, Shan; Liu, Yichang; Lei, Aiwen. Electrochemical Oxidative Cross-coupling with Hydrogen Evolution: A Green and Sustainable Way for Bond Formation. Chem. 2018, 4, 27-45
 
(20) Lu, Lijun; Pei, Xianglin; Mei, Yuan; Deng, Yi; Zhang, Heng; Zhang, Lina; Lei, Aiwen. Carbon Nanofibrous Microspheres Promote the Oxidative Double Carbonylation of Alkanes with CO. Chem. 2018, 4, 12, 2861-2871.
 
(21) Tang, Shan; Wang, Dan; Liu, Yichang; Zeng, Li; Lei, Aiwen. Cobalt-catalyzed electrooxidative C-H/N-H [4+2] annulation with ethylene or ethyne. Nature. Commun. 2018, 9, 798.
 
(22) Zhang Guoting; Lin, Yulin; Luo, Xu; Hu, Xia; Chen, Cong; Lei, Aiwen. Oxidative [4+2] annulation of styrenes with alkynes under external-oxidant-free conditons. Nat. Commun. 2018, 9, 1225.
 
(23) Tang, Shan; Zeng, Li; Lei, Aiwen. Oxidative R1-H/R2-H Cross-Coupling with Hydrogen Evolution. J. Am. Chem. Soc., 2018, 140, 13128-13135.
 
(24) Tang, Shan; Liu, Yichang; Gao, Xinlong; Wang, Pan; Huang, Pengfei; Lei, Aiwen. Multi-Metal-Catalyzed Oxidative Radical Alkynylation with Termianl Alkynes: A New Strategy for C(sp3)-C(sp) Bond Formation. J. Am. Chem. Soc. 2018, 140, 18, 6006–6013.
 
(25) Gao, Xinlong; Wang, Pan; Zeng, Li; Tang, Shan; Lei, Aiwen. Cobalt(II)-Catalyzed Electrooxidative C-H Amination of Arenes with Alkylamines. J. Am. Chem. Soc. 2018, 140, 4195-4199.
 
(26) Huang, Pengfei; Wang, Pan; Tang, Shan; Fu, Zhuangjiong; Lei, Aiwen. Electro-Oxidative S-H/S-H Cross-Coupling with Hydrogen Evolution: Facile Access to Unsymmetrical Disulfides. Angew. Chem. Int. Ed. 2018, 57, 8115-8119.
 
(27) Tang, Shan; Wang, Siyuan; Liu, Yichang; Cong, Hengjiang; Lei, Aiwen. Electrochemical Oxidative C-H Amination of Phenols: Access to Triarylamine Derivatives. Angew. Chem. Int. Ed. 2018, 130, 4827 –4831.
 
(28) Tang, Shan; Wang, Siyuan; Liu, Yichang; Cong, Hengjiang; Lei, Aiwen. Electrochemical oxidative C-H Amination of Phenols: Access to Triarylamine Derivatives. Angew. Chem. Int. Ed. 2018, 57, 4737 –4741.
 
(29) Hu, Xia; Zhang, Guoting; Bu, Faxiang; Lei, Aiwen. Selective Oxidative [4+2] Imine/Alkene Annulation with H2 Liberation Induced by Photo-Oxidation. Angew. Chem. Int. Ed. 2018, 57, 1286-1290.
 
(30) Yuan, Yong; Cao Yangmin; Lin, Yueping; Li, Yongli; Huang, Zhiliang; Lei, Aiwen. Electrochemical Oxidative Alkoxysulfonylation of Alkenes Using Sulfonyl Hydrazines and Alcohols with Hydrogen Evolution. ACS Catal. 2018, 8, 11, 10871–10875.
 
(31) Wang, Huamin; Li Yongli; Tang Zilu; Wang Shengchun; Heng, Zhang; Cong, Hengjiang; Lei, Aiwen. Z-Selective Addition of Diaryl Phosphine Oxides to Alkynes via Photoredox Catalysis. ACS Catal., 2018, 8, 11, 10599–10605.
 
(32) Yuan, Yong; Chen, Yixuan; Tang, Shan; Huang, Zhiliang; Lei, Aiwen. Electrochemical oxidative oxysulfenylation and aminosulfenylation of alkenes with hydrogen evolution. Sci. Adv.2018, 4, eaat5312.
 
(33) Zeng, Li; Li, Haoran; Tang, Shan; Gao, Xinlong; Deng, Yi; Zhang, Guoting; Pao, Chih-Wen; Chen, Jeng-Lung; Lee, Jyh-Fu; Lei, Aiwen. Cobalt-Catalyzed Electrochemical Oxidative C-H/N-H Carbonylation with Hydrogen Evolution. ACS Catal. 2018, 8, 5448-5453.
 
(34) Wu, Yong; Yi, Hong; Lei, Aiwen. Electrochemical Acceptorless Dehydrogenation of N-Heterocycles Utilizing TEMPO as Organo-Electrocatalyst. ACS Catal. 2018, 8, 1192-1196.
 
(35) Kirschner, Matthew S.; Ding, Wendu; Li, Yuxiu; Chapman, Craig T.; Lei, Aiwen; Lin, Xiao-Min; Chen, Lin X.; Schatz, George C.; Schaller, Richard D. Phonon-Driven Oscillatory Plasmonic Excitonic Nanomaterials. Nano. Lett. 2018, 18, 442-448.
 
(36) Song, Chunlan; Dong, Xin; Yi, Hong; Chiang, Chien-Wei; Lei, Aiwen. DDQ-Catalyzed Direct C(sp3)-H Amination of Alkylheteroarenes: Synthesis of Biheteroarenes under Aerobic and Metal-Free Conditions. ACS Catal. 2018, 8, 2195-2199.
 
(37) Liu, Kun; Tang, Shan; Huang, Pengfei; Lei, Aiwen. External oxidant-free electrooxidative [3 + 2] annulation between phenol and indole derivatives. Nature Commun. 20178, 775.

(38) Wang, Huaming; Lu, Qingquan; Chiang, Chien-Wei; Luo, Yi; Zhou, Jiufu; Wang, Guangyu; Lei, Aiwen. Markovnikov-Selective Radical Addition of S-Nucleophiles to Terminal Alkynes via Photoredox Process, Angew. Chem. Int. Ed. 2017, 129, 610-614.
(39) Yi, Hong; Niu, Linbin; Song, Chunlan; Li, Yiying; Dou, Bowen; Singh, Atul K; Lei, Aiwen.  Photocatalytic Dehydrogenative Cross-Coupling of Alkenes with Alcohols or Azoles without External Oxidant, Angew. Chem. Int. Ed. 2017, 56, 1120 –1124.
(40) Wang, Pan; Tang, Shan; Huang, Pengfei; Lei, Aiwen. Electrocatalytic Oxidant-Free Dehydrogenative C-H/S-H Cross Coupling, Angew. Chem. Int. Ed. 2017, 56, 3009-3013.
(41) Niu, Linbing; Yi, Hong; Wang, Shengchun; Liu, Tianyi; Liu, Jiamei; Lei, Aiwen. Photo-induced oxidant-free oxidative C–H/N–H cross-coupling between arenes and azoles, Nature Commun.2017, 8, DOI: 10.1038/ncomms14226.
(42) Yi, Hong; Yang, Dali; Xin, Jie; Qi, Xiaotian; Lan, Yu; Deng, Yi; Pao, Chih-Wen; Lee, Jyh-Fu; Lei, Aiwen. Unravelling the hidden link of lithium halides and application in the synthesis of organocuprates, Nature Commun.2017, 8, DOI: 10.1038/ncomms14794
(43) Yi, Hong; Zhang, Guoting; Wang, Huamin; Huang, Zhiyuan; Wang, Jue; Singh, Atul K.; Lei, Aiwen, Recent Advances in Radical C-H Activation/Radical Cross-Coupling. Chem. Rev. 2017117, 9016 – 9085.
(44) Crabtree, Robert H; Lei, Aiwen. Introduction: C-H Activation. Chem. Rev. 2017, 117, 8481 – 8482.
(45) Kirschner, Matthew S; Ding, Wendu; Li, Yuxiu; Chapman, Craig T; Lei Aiwen; Lin, Xiao-Min; Chen, Lin X; Schatz, George C; Schaller, Richard D. Phonon-Driven Oscillatory Plasmonic Excitonic Nanomaterials. Nano Lett. 2017, DOI: 10.1021/acs.nanolett.7b04354.
(46) Niu, Linbin; Liu, Jiamei; Yi, Hong; Wang, Shengchun; Liang, Xing-An; Singh, Atul K; Chiang, Chien-Wei; Lei, Aiwen. Visible-Light-Induced External Oxidant-Free Oxidative Phosphonylation of C(sp2)-H Bonds. ACS Catalysis20177, 7412 – 7416.
 
(47) Hu, Xia; Zhang,Guoting; Bu,Faxiang; Lei, Aiwen. Visible-Light-Mediated Anti-Markovnikov Hydration of Olefins. ACS Catal.2017, 7, 1432–1437.
 
(48) Wu, Jiwei; Zhou, Yi; Zhou, Yuchen; Chiang, Chien-Wei; Lei, Aiwen. Electro-Oxidative C(sp3)-H Amination of Azoles via Intermolecular Oxidative C(sp3)-H/N-H Cross-Coupling. ACS Catal. 20177, 8320-8323.
 
(49) Tang, Shan; Wang, Pan; Li, Haoran; Lei, Aiwen, Multimetallic Catalyzed Radical Oxidative C(sp3)–H/C(sp)–H Cross-Coupling between Unactivated Alkanes and Terminal Alkynes, Nat. Commun. 2016, 7, 11676.
 
(50) Wu. Qian; Luo, Yi; Lei, Aiwen; You, Jingsong, Aerobic Copper-Promoted Radical-Type Cleavage of Coordinated Cyanide Anion: Nitrogen Transfer to Aldehydes to Form Nitriles. J. Am. Chem. Soc. 2016138, 2885-2888.
 
(51) Zhang, Guoting; Hu, Xia; Chiang, Chien-Wei; Yi, Hong; Pei, Pengkun; Singh, Atul K.; Lei, Aiwen, Anti-Markovnikov Oxidation of β-Alkyl Styrenes with H2O as the Terminal Oxidant, J. Am. Chem. Soc. 2016, 138, 12037-12040.
 
(52) Wang, Huamin; Lu, Qingquan; Qian, Chaohang; Liu, Chao; Liu, Wei; Chen, Kai; Lei, Aiwen, Solvent-Enabled Radical Selectivities: Controlled Syntheses of Sulfoxides and Sulfides. Angew. Chem. Int. Ed. 2016, 55, 1094-1097.
 
(53) Li, Wu; Duan, Zhengli; Zhang, Xueye; Zhang, Heng; Wang, Mengfan; Jiang, Ru;  Zeng, Hongyao; Liu, Chao; Lei, Aiwen, From Anilines to Isatins: Oxidative Palladium-Catalyzed Double Carbonylation of C−H Bonds. Angew. Chem. Int. Ed. 201554, 1893-1896.
 
(54) Liu, Jianming; Zhang, Xin; Yi, Hong; Liu, Chao; Liu, Ren; Zhang, Heng; Zhuo, Kelei; Lei, Aiwen, Chloroacetate-Promoted Selective Oxidation of Heterobenzylic Methylenes under Copper Catalysis. Angew. Chem. Int. Ed. 201554, 1261-1265.
 
(55) Tang, Shan; Liu, Kun; Liu, Chao; Lei, Aiwen, Olefinic C–H Functionalization through Radical Alkenylation. Chem. Soc. Rev. 2015, 44, 1070-1082.
 
(56) Ke, Jie; Tang, Yuliang; Yi, Hong; Li, Yali; Cheng, Yongde; Liu, Chao; Lei, Aiwen, Copper-Catalyzed Radical/Radical C(sp3)-H/P-H Cross-Coupling: α-Phosphorylation of Aryl Ketone O-Acetyloximes. Angew. Chem. Int. Ed. 201554, 6604-6607.
 
(57) Zhang, Guoting; Liu, Chao; Yi, Hong; Meng, Qingyuan; Bian, Changliang; Chen, Hong; Jian, Jing-Xin; Wu, Li-Zhu; Lei, Aiwen, External Oxidant-Free Oxidative Cross-Coupling: A Photoredox Cobalt-Catalyzed Aromatic C-H Thiolation for Constructing C-S Bonds. J. Am. Chem. Soc. 2015137, 9273-9280.
 
(58) Tang, Shan; Zeng, Li; Liu, Yichang; Lei, Aiwen, Zinc-Catalyzed Dehydrogenative Cross-Coupling of Terminal Alkynes with Aldehydes: Access to Ynones. Angew. Chem. Int. Ed. 2015, 54, 15850-15853.
 
(59) Liu, Chao; Yuan, Jiwen; Gao, Meng; Tang, Shan; Li, Wu; Shi, Renyi; Lei, Aiwen, Oxidative Coupling between Two Hydrocarbons: An Update of Recent C-H Functionalizations. Chem. Rev. 2015115, 12138-12204.
 
(60) Wu, Kun; Huang, Zhiliang; Qi, Xiaotian; Li, Yingzi; Zhang, Guanghui; Liu, Chao; Yi, Hong; Meng, Lingkui; Bunel, Emilio E.; Miller, Jeffrey T.; Pao, Chih-Wen; Lee, Jyh-Fu; Lan, Yu; Lei, Aiwen, Copper-Catalyzed Aerobic Oxidative Coupling: From Ketone and Diamine to Pyrazine. Sci. Adv. 2015, 1, e1500656.
 
(61) Zhang, G. H.; Yi, H.; Zhang, G. T.; Deng, Y.; Bai, R. P.; Zhang, H.; Miller, J. T.; Kropf, A.J.; Bunel, E.E.; Lei, A. W., Direct Observation of Reduction of Cu(II) to Cu(I) by Terminal Alkynes. J. Am. Chem. Soc. 2014, 136, 924-926.
 
(62) Liu, J.; Liu, Q.; Yi, H.; Qin, C.; Bai, R. P.; Qi, X. T.; Lan, Y.; Lei, A. W., Visible Light Mediated Decarboxylation / Oxidative Amidation of α-Keto Acids with Amines under Mild Conditions Using O2. Angew Chem Int Ed. 2014, 53, 502.
 
(63)Li, W.; Liu, C.; Zhang, H.; Ye, K.Y.; Zhang, G. H.; Zhang, W. Z.; Duan, Z. L.; You, S. L.; Lei, A. W., Palladium-Catalyzed Oxidative Carbonylation of N-allylamines for the synthesis of â-lactams. Angew Chem Int Ed. 2014, 53, 2443.
 
(64)Wang, L.; Wang, Y. X.; Liu, C.; Lei, A. W., CO/C-H as the Acylative Reagent: A Palladium-Catalyzed Aerobic Oxidative Carbonylative Esterfication of Alcohols. Angew Chem Int Ed. 2014, 53, 5657.
(65) Bai, R.P.; Zhang, G.Y.; Yi, H.; Huang, Z.L.; Qi, X.T.; Liu, C.; Miller, J. T; Kropf, A. J.; Bunel E. E.; Lan, Yu.; Lei, A.W. Cu(II)/Cu(I)-Synergistic Cooperation to Lead the Alkyne C-H Activation. J. Am. Chem. Soc. 2014136, 16760–16763.
(66) Liu, C.; Liu, D.; Lei, A. W., Recent Advance of Transition-Metal Catalyzed Radical Oxidative Cross-Couplings. Acc. Chem. Res. 2014, 47, 3459−3470.
(67) He, C.; Zhang, G. H.; Ke, J.; Zhang, H.; Miller, J. T.; Kropf, A. J.; Lei, A. W., Labile Cu(I)-Catalyst/Spectator Cu(II)-Species in Copper-Catalyzed C-C Coupling Reaction: Operando IR, In situ XANES/EXAFS Evidence and Kinetic Investigations. J. Am. Chem. Soc. 2013135, 488.
(68) Lu, Q. Q.; Zhang, J.; Zhao, G. L.; Qi, Y.; Wang, H. M.; Lei, A. W., Dioxygen-Triggered Oxidative Radical Reaction: Direct Aerobic Difunctionalization of Terminal Alkynes towards β-Keto Sulfones. J. Am. Chem. Soc.  2013135, 11481.
(69) Muto, K.; Yamaguchi, J.; Lei, A. W.; Itami, K., Isolation, Structure, and Reactivity of an Arylnickel(II) Pivalate Complex in Catalytic C-H/C-O Biaryl Coupling. J. Am. Chem. Soc.  2013135, 16384.
(70) He, C.; Ke, J.; Xu, H.; Lei, A. W., Insights toward the Symbiotic Catalysis Sonogashira Coupling Reaction: Quantitative Kinetic Investigation of Transmetalation.  Angew Chem Int Edit.  201352, 1527.
(71) Wang, J.; Liu, C.; Yuan, J. W.; Lei, A. W., Copper-Catalyzed Oxidative Coupling of Alkenes with Aldehydes: Direct Access to α, β-unsaturated Ketones. Angew Chem Int Edit. 201352, 2256.
(72) Liu, D.; Liu, C.; Li, H.; Lei, A. W., Direct Funtionalization of Tetrahydrofuran and 1,4-Dioxane: A Nickel-Catalyzed Oxidative Csp3-H Arylation. Angew Chem Int Ed. 201352, 4453.
(73) Gao, M.; He, C.; Chen, H. Y.; Bai, R. P.; Cheng, B.; Lei, A. W., Synthesis of Pyrrole by Click Reaction: Silver-Catalyzed Cycloaddition of Terminal Alkynes with isocyanides. Angew Chem Int Edit. 201352, 6958.
(74) Huang, Z. L.; Jin, L. Q.; Feng, Y.; Peng, P.; Yi, H.; Lei, A. W., Iron-Catalyzed Oxidative Radical Cross-Coupling/Cyclization between Phenol and Olefin. Angew Chem Int Edit. 201352, 7151.
(75) Lu, Q. Q.; Zhang, J.; Wei, F. L.; Qi, Y.; Wang, H. M.; Liu, Z. L.; Lei, A. W. Dioxygen Activation by Sulfinic Acids: Direct Oxysulfonylation of Alkenes Leading to Secondary and Tertiary β-Hydroxysulfones. Angew Chem Int Ed. 201352, 7156.
 
(76) Meng, L. K.; Zhang, G. H.; Liu, C.; Wu, K.; Lei, A. W. Trifluoromethanesulfonic Acid Catalyzed Synergetic Oxidative / [3+2] Cyclization of Quinones with Olefins. Angew Chem Int Edit. 201352, 10195-10198.
 
(77) Shi, R. Y.; Zhang, H.; Lu, L. J.; Chen, B. R.; Sha, Y. C.; Liu, C.; Lei, A. W. Palladium / Copper-Catalyzed Oxidative C-H Alkenylation/N-Dealkylative Carbonylation of Tertiary Anilines. Angew Chem Int Edit. 201352, 10582.
 
(78) Guo, M.; Dong, H.; Li, J.; Cheng, B.; Huang, Y. Q.; Feng, Y. Q.; Lei, A. W. Spectroscopic Observation of Iodosylarene Metalloporphyrin Adducts and Manganese(V)-Oxo Porphyrin Species in a Cytochrome P450 Analogue. Nat commun. 2012, 3, 1190.
 
(79) He, C.; Guo, S.; Ke, J.; Hao, J.; Xu, H.; Chen, H. Y.; Lei, A. W. Silver-Mediated Oxidative C-H/C-H Functionalization: A Strategy To Construct Polysubstituted Furans. J. Am. Chem. Soc. 2012, 134, 5766.
 
(80) Zhang, H.; Shi, R. Y.; Ding, A. X.; Lu, L. J.; Chen, B. R.; Lei, A. W. Transition-metal-free Alkoxycarbonylation of Aryl Halides. Angew Chem Int Edit. 2012, 51, 12542.
 
(81) Weng, Y.; Cheng, B.; He, C.; Lei, A. W. Rational Design of Pd-Catalyzed Csp-Csp Cross-Coupling Reaction Inspired by Kinetic Studies. Angew Chem Int Edit. 2012, 51, 9547.
 
(82) Liu, C.; Tang, S.; Zheng, L.; Liu, D.; Zhang, H.; Lei, A. W. Covalently Bound Benzyl Ligand Promotes Selective Palladium-Catalyzed Oxidative Esterification of Aldehydes with Alcohols. Angew Chem Int Edit. 2012, 51, 5662.
 
(83) Zhang, H.; Shi, R. Y.; Gan, P.; Liu, C.; Ding, A. X.; Wang, Q. Y.; Lei, A. W. Palladium-Catalyzed Oxidative Double C-H Functionalization/Carbonylation for the Synthesis of Xanthones. Angew Chem Int Edit. 2012, 51, 5204.
 
(84) Liu, Q.; Wu, P.; Yang, Y. H.; Zeng, Z. Q.; Liu, J.; Yi, H.; Lei, A. W. Room-Temperature Copper-Catalyzed Oxidation of Electron-Deficient Arenes and Heteroarenes Using Air. Angew Chem Int Edit. 2012, 51, 4666.
 
(85) Liu, C.; Tang, S.; Liu, D.; Yuan, J. W.; Zheng, L. W.; Meng, L. K; Lei, A. W. Nickel-Catalyzed Heck-Type Alkenylation of Secondary and Tertiary a-Carbonyl Alkyl Bromides. Angew Chem Int Edit. 2012, 51, 3638.
 
(86) Liu, C.; Zhang, H.; Shi, W.; Lei, A. W. Bond Formations between Two Nucleophiles: Transition Metal Catalyzed Oxidative Cross-Coupling Reactions. Chem Rev. 2011, 111, 1780.
 
(87) Shi, W.; Liu, C.; Lei, A. W. Transition-metal catalyzed oxidative cross-coupling reactions to form C-C bonds involving organometallic reagents as nucleophiles. Chem Soc Rev. 2011, 40, 2761.
 
(88) Liu, Q.; Zhang, H.; Lei, A. W. Oxidative Carbonylation Reactions: Organometallic Compounds (R-M) or Hydrocarbons (R-H) as Nucleophiles. Angew Chem Int Edit. 2011, 50, 10788.
 
(89) Liu, C.; Wang, J.; Meng, L. K.; Deng, Y.; Li, Y.; Lei, A. W. Palladium-Catalyzed Aerobic Oxidative Direct Esterification of Alcohols. Angew Chem Int Edit. 2011, 50, 5144.
 
(90) Liu, C.; Deng, Y.; Wang, J.; Yang, Y. Y.; Tang, S.; Lei, A. W. Palladium-Catalyzed C-C Bond Formation To Construct 1,4-Diketones under Mild Conditions. Angew Chem Int Edit. 2011, 50, 7337.
 
(91) Liu, W.; Cao, H.; Zhang, H.; Zhang, H.; Chung, K. H.; He, C. A.; Wang, H. B.; Kwong, F. Y.; Lei, A. W., Organocatalysis in Cross-Coupling: DMEDA-Catalyzed Direct C-H Arylation of Unactivated Benzene. J. Am. Chem. Soc. 2010, 132, 16737.
 
(92) Hu, Y. H.; Liu, J.; Lu, Z. X.; Luo, X. C.; Zhang, H.; Lan, Y.; Lei, A. W., Base-Induced Mechanistic Variation in Palladium-Catalyzed Carbonylation of Aryl Iodides.  J. Am. Chem. Soc. 2010, 132, 3153.
 
(93) Jin, L. Q.; Xin, J.; Huang, Z. L.; He, J.; Lei, A. W., Transmetalation is the Rate-Limiting Step: Quantitative Kinetic Investigation of Nickel-Catalyzed Oxidative Coupling of Arylzinc Reagents. J. Am. Chem. Soc. 2010, 132, 9607.
 
(94) He, C. A.; Guo, S.; Huang, L.; Lei, A. W., Copper Catalyzed Arylation/C-C Bond Activation: An Approach toward alpha-Aryl Ketones. J. Am. Chem. Soc. 2010, 132, 8273.
 
(95) Chen, M.; Zheng, X. L.; Li, W. Q.; He, J.; Lei, A. W., Palladium-Catalyzed Aerobic Oxidative Cross-Coupling Reactions of Terminal Alkynes with Alkylzinc Reagents.  J. Am. Chem. Soc. 2010, 132, 4101.
 
(96) Liu, W.; Cao, H.; Lei, A. W., Iron-Catalyzed Direct Arylation of Unactivated Arenes with Aryl Halides. Angew Chem Int Edit. 2010, 49, 2004.
 
(97) Liu, Q.; Li, G.; He, J.; Liu, J.; Li, P.; Lei, A. W., Palladium-Catalyzed Aerobic Oxidative Carbonylation of Arylboronate Esters under Mild Conditions.  Angew Chem Int Edit. 2010, 49, 3371.
 
(98) Duan, H.; Meng, L. K.; Bao, D. H.; Zhang, H.; Li, Y.; Lei, A. W., Zinc Chloride Enhanced Arylations of Secondary Benzyl Trifluoroacetates in the Presence of beta-Hydrogen Atoms. Angew Chem Int Edit. 2010, 49, 6387.
 
(99) Liu, Q.; Lan, Y.; Liu, J.; Li, G.; Wu, Y. D.; Lei, A. W., Revealing a Second Transmetalation Step in the Negishi Coupling and Its Competition with Reductive Elimination: Improvement in the Interpretation of the Mechanism of Biaryl Syntheses.  J. Am. Chem. Soc. 2009, 131, 10201.
(100) Jin, L. Q.; Zhang, H.; Li, P.; Sowa, J. R.; Lei, A. W., What is the Rate of the Csp(2)-Csp(2) Reductive Elimination Step? Revealing an Unusually Fast Ni-Catalyzed Negishi-Type Oxidative Coupling Reaction. J. Am. Chem. Soc. 2009, 131, 9892.
(101) Jin, L. Q.; Liu, C.; Liu, J.; Hu, F.; Lan, Y.; Batsanov, A. S.; Howard, J. A. K.; Marder, T. B.; Lei, A. W., Revelation of the Difference between Arylzinc Reagents Prepared from Aryl Grignard and Aryllithium Reagents Respectively: Kinetic and Structural Features. J. Am. Chem. Soc. 2009, 131, 16656.
(102) Chen, J.; Zhang, W. C.; Geng, H. L.; Li, W.; Hou, G. H.; Lei, A. W.; Zhang, X. M., Efficient Synthesis of Chiral beta-Arylisopropylamines by Using Catalytic Asymmetric Hydrogenation. Angew Chem Int Edit. 2009, 48, 800.
 
(103) Zhao, Y. S.; Jin, L. Q.; Li, P.; Lei, A. W., Palladium-catalyzed oxidative carbonylation of alkyl and aryl indium reagents with CO under mild conditions. J. Am. Chem. Soc. 2008, 130, 9429.
 
(104) Shi, W.; Luo, Y. D.; Luo, X. C.; Chao, L.; Zhang, H.; Wang, J.; Lei, A. W., Investigation of an Efficient Palladium-Catalyzed C(sp)-C(sp) Cross-Coupling Reaction Using Phosphine-Olefin Ligand: Application and Mechanistic Aspects. J. Am. Chem. Soc. 2008, 130, 14713.
(105) He, C.; Chen, C.; Cheng, J.; Liu, C.; Liu, W.; Li, Q.; Lei, A. W., Aryl halide tolerated electrophilic amination of arylboronic acids with N-chloroamides catalyzed by CuCl at room temperature.  Angew Chem Int Edit. 2008, 47, 6414.
 
(106) Chen, M.; Weng, Y.; Guo, M.; Zhang, H.; Lei, A. W., Nickel-catalyzed reductive cyclization of unactivated 1,6-enynes in the presence of organozinc reagents.  Angew Chem Int Edit. 2008, 47, 2279.
 
(107) Zhao, Y. S.; Wang, H. B.; Hou, X. H.; Hu, Y. H.; Lei, A. W.; Zhang, H.; Zhu, L. Z., Oxidative cross-coupling through double transmetallation: Surprisingly high selectivity for palladium-catalyzed cross-coupling of alkylzinc and alkynylstannanes. J. Am. Chem. Soc. 2006, 128, 15048.

(108) 
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