2010 & Before

Organocatalysis in Cross-Coupling: DMEDA-Catalyzed Direct C-H Arylation of Unactivated Benzene.
Liu, W.; Cao, H.; Zhang, H.; Zhang, H.; Chung, K. H.; He, C. A.; Wang, H. B.; Kwong, F. Y.; Lei, A. W.
J. Am. Chem. Soc., 2010, 132, 16737-16740.

Link: http://pubs.acs.org/doi/pdf/10.1021/ja103050x

Base-Induced Mechanistic Variation in Palladium-Catalyzed Carbonylation of Aryl Iodides.
Hu, Y. H.; Liu, J.; Lu, Z. X.; Luo, X. C.; Zhang, H.; Lan, Y.; Lei, A. W.
J. Am. Chem. Soc., 2010, 132, 3153-3158

Link: http://pubs.acs.org/doi/pdf/10.1021/ja909962f

Transmetalation is the Rate-Limiting Step: Quantitative Kinetic Investigation of Nickel-Catalyzed Oxidative Coupling of Arylzinc Reagents.
Jin, L. Q.; Xin, J.; Huang, Z. L.; He, J.; Lei, A. W.
J. Am. Chem. Soc., 2010, 132, 9607.

Link: http://pubs.acs.org/doi/pdf/10.1021/ja1045296

Copper Catalyzed Arylation/C-C Bond Activation: An Approach toward alpha-Aryl Ketones.
He, C. A.; Guo, S.; Huang, L.; Lei, A. W.
J. Am. Chem. Soc., 2010, 132, 8273-8275.

Link: http://pubs.acs.org/doi/pdf/10.1021/ja1033777

Palladium-Catalyzed Aerobic Oxidative Cross-Coupling Reactions of Terminal Alkynes with Alkylzinc Reagents.

Chen, M.; Zheng, X. L.; Li, W. Q.; He, J.; Lei, A. W.
J. Am. Chem. Soc., 2010, 132, 4101-4103.

Link: http://pubs.acs.org/doi/pdf/10.1021/ja100630p

Iron-Catalyzed Direct Arylation of Unactivated Arenes with Aryl Halides.
Liu, W.; Cao, H.; Lei, A. W.
 Angew Chem Int Ed., 2010, 49, 2048-2052.

Link: http://onlinelibrary.wiley.com/doi/10.1002/ange.200906870/epdf

Palladium-Catalyzed Aerobic Oxidative Carbonylation of Arylboronate Esters under Mild Conditions.
Liu, Qiang; Li, Gang; He, Jun; Liu, Jing; Li, Peng; Lei, Aiwen
Angew Chem Int Edit 2010, 49, 3371.

Link: http://onlinelibrary.wiley.com/doi/10.1002/anie.201000460/epdf

Zinc Chloride Enhanced Arylations of Secondary Benzyl Trifluoroacetates in the Presence of beta-Hydrogen Atoms.
Duan, Hui; Meng, Lingkui; Bao, Denghui; Zhang, Heng; Li, Yao; Lei, Aiwen
Angew Chem Int Edit 2010, 49, 6387.

Link: http://onlinelibrary.wiley.com/doi/10.1002/anie.201002116/epdf

Arylation of unactivated arenes.
Aiwen Lei*, Wei Liu, Chao Liu and Mao Chen
Dalton T 2010, 39, 10352

Link: http://pubs.rsc.org/en/content/articlelanding/2010/dt/c0dt00486c#!divAbstract

Transition-Metal-Catalyzed Oxidative Cross-Coupling Reactions.
Liu, Chao; Liu, Dong; Lei, Aiwen
Synlett 2010, 2527.

Link: https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0030-1258802.pdf

A novel self-promoted Morita-Baylis-Hillman-like dimerization.
Li, Qiang; Wongkhan, Kittiya; Luo, Xian Cai; Batsanov, Andrei S.; Howard, Judith A. K.; Lan, Yu; Wu, Yun Dong; Marder, Todd B.; Lei, A.W.
Chinese Sci Bull 2010, 55, 2794.
Link: https://link.springer.com/article/10.1007%2Fs11434-010-3270-9

Asymmetric Cycloisomerization of 1, n-Enynes Catalyzed by Transition Metals.
Chen, Mao; Weng, Yue; Lei, Aiwen
Prog Chem 2010, 22, 1341.

Revealing a Second Transmetalation Step in the Negishi Coupling and Its Competition with Reductive Elimination: Improvement in the Interpretation of the Mechanism of Biaryl Syntheses.
Liu, Qiang; Lan, Yu; Liu, Jing; Li, Gang; Wu, Yun-Dong; Lei, Aiwen
J Am Chem Soc 2009, 131, 10201.

Link: http://pubs.acs.org/doi/abs/10.1021/ja908198d

What is the Rate of the Csp(2)-Csp(2) Reductive Elimination Step? Revealing an Unusually Fast Ni-Catalyzed Negishi-Type Oxidative Coupling Reaction.
Jin, Liqun; Zhang, Hua; Li, Peng; Sowa, John R.; Lei, Aiwen
J Am Chem Soc 2009, 131, 9892.

Link: http://pubs.acs.org/doi/abs/10.1021/ja903833u?journalCode=jacsat&quickLinkVolume=131&quickLinkPage=9892&selectedTab=citation&volume=131

Revelation of the Difference between Arylzinc Reagents Prepared from Aryl Grignard and Aryllithium Reagents Respectively: Kinetic and Structural Features.
Jin, Liqun; Liu, Chao; Liu, Jing; Hu, Fang; Lan, Yu; Batsanov, Andrei S.; Howard, Judith A. K.; Marder, Todd B.; Lei, Aiwen
J Am Chem Soc 2009, 131, 16656.

Link: http://pubs.acs.org/doi/abs/10.1021/ja903277d

Efficient Synthesis of Chiral beta-Arylisopropylamines by Using Catalytic Asymmetric Hydrogenation.
Chen, Jian; Zhang, Weicheng; Geng, Huiling; Li, Wei; Hou, Guohua; Lei, Aiwen; Zhang, Xumu
Angew Chem Int Edit 2009, 48, 800.

Link: http://onlinelibrary.wiley.com/doi/10.1002/anie.200805058/epdf

Acceleration of Reductive Elimination of [Ar-Pd-C-sp3] by a Phosphine/Electron-Deficient Olefin Ligand: A Kinetic Investigation.
Zhang, H.; Luo, X. C.; Wongkhan, K.; Duan, H.; Li, Q.; Zhu, L. Z.; Wang, J.; Batsanov, A. S.; Howard, J. A. K.; Marder, T. B.; Lei, A. W.,
Chem-Eur J 2009, 15, 3823.

Link: http://onlinelibrary.wiley.com/doi/10.1002/chem.200802209/abstract

Identification of a Highly Efficient Alkylated Pincer Thioimido-Palladium(II) Complex as the Active Catalyst in Negishi Coupling.
Liu, Jing; Wang, Haibo; Zhang, Heng; Wu, Xiaojun; Zhang, Hua; Deng, Yi; Yang, Zhen; Lei, Aiwen
Chem-Eur J 2009, 15, 4437.

Link: http://onlinelibrary.wiley.com/doi/10.1002/chem.200802238/abstract;jsessionid=AAC0DCDAE18CCC469C4C0D24A29B3F8C.f04t02

Pincer Thioamide and Pincer Thioimide Palladium Complexes Catalyze Highly Efficient Negishi Coupling of Primary and Secondary Alkyl Zinc Reagents at Room Temperature.
Wang, Haibo; Liu, Jing; Deng, Yi; Min, Tianyin; Yu, Ganxiang; Wu, Xiaojun; Yang, Zhen; Lei, Aiwen
Chem-Eur J 2009, 15, 1499.

Link: http://onlinelibrary.wiley.com/doi/10.1002/chem.200801860/full

Nickel-Catalyzed Oxidative Coupling Reactions of Two Different Terminal Alkynes Using O-2 as the Oxidant at Room Temperature: Facile Syntheses of Unsymmetric 1,3-Diynes.
Yin, W. Y.; He, C.; Chen, M.; Zhang, H.; Lei, A. W.,
Org Lett 2009, 11, 709.

Link: http://pubs.acs.org/doi/abs/10.1021/ol8027863?journalCode=orlef7&quickLinkVolume=11&quickLinkPage=709&selectedTab=citation&volume=11

Highly Selective Palladium-Catalyzed Oxidative Csp(2)-Csp(3) Cross-Coupling of Arylzinc and Alkylindium Reagents through Double Transmetallation.
Jin, Liqun; Zhao, Yingsheng; Zhu, Lizheng; Zhang, Heng; Lei, Aiwen
Adv Synth Catal 2009, 351, 630.

Link: http://onlinelibrary.wiley.com/doi/10.1002/adsc.200800703/pdf

Synthesis, chromatographic evaluation and hydrophilic interaction/reversed-phase mixed-mode behavior of a "Click beta-cyclodextrin" stationary phase.
Guo, Zhimou; Jin, Yu; Liang, Tu; Liu, Yanfang; Xu, Qing; Liang, Xinmiao; Lei, Aiwen
J Chromatogr A 2009, 1216, 257.

Link: https://www.sciencedirect.com/science/article/pii/S0021967308021080?via%3Dihubhttps://www.sciencedirect.com/science/article/pii/S0021967308021080?via%3Dihub

Palladium-catalyzed oxidative carbonylation of alkyl and aryl indium reagents with CO under mild conditions.
Zhao, Y. S.; Jin, L. Q.; Li, P.; Lei, A. W.,
J Am Chem Soc 2008, 130, 9429.

Link: http://pubs.acs.org/doi/abs/10.1021/ja801116s?journalCode=jacsat&quickLinkVolume=130&quickLinkPage=9429&selectedTab=citation&volume=130

Investigation of an Efficient Palladium-Catalyzed C(sp)-C(sp) Cross-Coupling Reaction Using Phosphine-Olefin Ligand: Application and Mechanistic Aspects.
Shi, W.; Luo, Y. D.; Luo, X. C.; Chao, L.; Zhang, H.; Wang, J.; Lei, A. W.,
J Am Chem Soc 2008, 130, 14713.

Link: http://pubs.acs.org/doi/abs/10.1021/ja8049436?journalCode=jacsat&quickLinkVolume=130&quickLinkPage=14713&selectedTab=citation&volume=130

Aryl halide tolerated electrophilic amination of arylboronic acids with N-chloroamides catalyzed by CuCl at room temperature.
He, Chuan; Chen, Chong; Cheng, Jin; Liu, Chao; Liu, Wei; Li, Qiang; Lei, Aiwen
Angew Chem Int Edit 2008, 47, 6414.

 Link: http://onlinelibrary.wiley.com/doi/10.1002/anie.200801427/epdf

Nickel-catalyzed reductive cyclization of unactivated 1,6-enynes in the presence of organozinc reagents.
Chen, Mao; Weng, Yue; Guo, Mian; Zhang, Hua; Lei, Aiwen
Angew Chem Int Edit 2008, 47, 2279.

 Link: http://onlinelibrary.wiley.com/doi/10.1002/anie.200704452/epdf

Effective Pd-nanoparticle (PdNP)-catalyzed Negishi coupling involving alkylzinc reagents at room temperature.
Liu, J.; Deng, Y.; Wang, H. B.; Zhang, H.; Yu, G. X.; Wu, B. B.; Zhang, H.; Li, Q.; Marder, T. B.; Yang, Z.; Lei, A. W.,
Org Lett 2008, 10, 2661.

 Link: http://pubs.acs.org/doi/abs/10.1021/ol8007342?journalCode=orlef7&quickLinkVolume=10&quickLinkPage=2661&selectedTab=citation&volume=10

A convenient synthesis and the asymmetric hydrogenation of N-phthaloyl dehydroamino acid esters.
Chen, J.; Liu, Q.; Zhang, W. C.; Spinella, S.; Lei, A. W.; Zhang, X. M.,
Org Lett 2008, 10, 3033.

 Link:  http://pubs.acs.org/doi/abs/10.1021/ol800996j?journalCode=orlef7&quickLinkVolume=10&quickLinkPage=3033&selectedTab=citation&volume=10

An electron-deficient diene as ligand for palladium-catalyzed cross-coupling reactions: An efficient alkylation of aryl iodides by primary and secondary alkylzinc reagents.
Liu, Qiang; Duan, Hui; Luo, Xiancai; Tang, Yang; Li, Gang; Huang, Rong; Lei, Aiwen
Adv Synth Catal 2008, 350, 1349.

Link: http://onlinelibrary.wiley.com/doi/10.1002/adsc.200800118/abstract?

Efficient Fe-catalyzed homo-coupling of aryl Grignard reagents using O-2 as the oxidant.
Liu, W.; Lei, A. W.,
Tetrahedron Lett 2008, 49, 610.

Link: http://www.sciencedirect.com/science/article/pii/S0040403907023489

Alkoxycarbonylation of aryl iodides catalyzed by Pd with a thiourea type ligand under balloon pressure of CO.
Liu, J.; Liang, B.; Shu, D. X.; Hu, Y. H.; Yang, Z.; Lei, A. W.,
Tetrahedron 2008, 64, 9581.

Link: http://www.sciencedirect.com/science/article/pii/S0040402008013410

Palladium-catalyzed R(sp(3))-Zn/R(sp)-SnBu3 oxidative cross-coupling.
Jin, Liqun; Zhao, Yingsheng; Wang, Haibo; Lei, Aiwen
Synthesis 2008, 649

Link: https://www.thieme-connect.de/DOI/DOI?10.1055/s-2007-990863

Novel reversed-phase high-performance liquid chromatography stationary phase with oligo(ethylene glycol) "click" to silica.
Zhimou Guo, Yanfang Liu, Junyan Xu, Qing Xu, Xingya Xue, Feifang Zhang, Yanxiong Ke, Xinmiao Liang, Aiwen Lei*
J Chromatogr A 2008, 1191, 78.

Link: http://www.sciencedirect.com/science/article/pii/S0021967307020109?via%3Dihub

Preparation of novel beta-cyclodextrin chiral stationary phase based on click chemistry.
Yongping Zhang, Zhimou Guo, Jinxing Ye, Qing Xu, Xinmiao Liang, Aiwen Lei*
J Chromatogr A 2008, 1191, 188.

Link: http://www.sciencedirect.com/science/article/pii/S0021967307019462?via%3Dihub

Alkynylation of alpha-halocarbonyl compounds - a Stille-type cross-coupling for the formation of C(sp)-C(sp(3)) bonds under neutral conditions.
Wei Shi, Chao Liu, Zai Yua and Aiwen Lei*
Chem Commun 2007, 2342.

Link:  http://pubs.rsc.org/en/content/articlelanding/2007/cc/b703221h#!divAbstract

"Click saccharides'': novel separation materials for hydrophilic interaction liquid chromatography.
Zhimou Guo, Aiwen Lei,* Yongping Zhang, Qing Xu, Xingya Xue, Feifang Zhang  and Xinmiao Liang*
Chem Commun 2007, 2491.

Link: http://pubs.rsc.org/en/content/articlelanding/2007/cc/b701831b#!divAbstract

Superior effect of a pi-acceptor ligand (Phosphine-Electron-Deficient olefin ligand) in the Negishi coupling involving alkylzinc reagents.
Xiancai Luo, Heng Zhang, Hui Duan, Qiang Liu, Lizheng Zhu, Tony Zhang,  andAiwen Lei*
Org Lett 2007, 9, 4571.

Link: http://pubs.acs.org/doi/abs/10.1021/ol701995t

Ni-catalyzed mild arylation of alpha-halocarbonyl compounds with arylboronic acids.
Chao Liu, Chuan He, Wei Shi, Mao Chen, and Aiwen Lei*
Org Lett 2007, 9, 5601.

Link: http://pubs.acs.org/doi/abs/10.1021/ol702456z

Rh-catalyzed highly enantioselective formation of functionalized cyclopentanes and cyclopentanones.
Fei Liu, Qiang Liu, Minsheng He, Xumu Zhang* and Aiwen Lei*
Org Biomol Chem 2007, 5, 3531.

Link: http://pubs.rsc.org/en/content/articlelanding/2007/ob/b712396e#!divAbstract

Effect of lithium chloride on tuning the reactivity of Pauson-Khand reactions catalyzed by palladium-tetramethylthiourea.
Lu-Jiang Denga, Jing Liua, Ji-Qing Huanga, Yanhe Hud, Mao Chend, Yu Lana, Jia-Hua Chen* Aiwen Lei*
Synthesis 2007,  2565.

Link: https://www.thieme-connect.de/DOI/DOI?10.1055/s-2007-983796

Oxidative cross-coupling through double transmetallation: Surprisingly high selectivity for palladium-catalyzed cross-coupling of alkylzinc and alkynylstannanes.
Yingsheng Zhao, Haibo Wang, Xiaohui Hou, Yanhe Hu, Aiwen Lei*, Heng Zhang*, and Lizheng Zhu
J. Am. Chem. Soc. 2006, 128, 15048.

Link: http://pubs.acs.org/doi/abs/10.1021/ja0647351

Click chemistry: a new facile and efficient strategy for preparation of functionalized HPLC packings.
Zhimou Guo, Aiwen Lei,* Xinmiao Liang* and   Qing Xu
Chem Commun 2006, 4512.

Link: http://pubs.rsc.org/en/content/articlelanding/2006/cc/b610733h#!divAbstract

Asymmetric hydrogenation of pyridines: Enantioselective synthesis of nipecotic acid derivatives.
Lei, Aiwen; Chen, Mao; He, Minsheng; Zhang, Xumu
Eur J Org Chem 2006, 4343.