New Paper:Heteroaromatic imidazo[1,2-a]pyridines synthesis from C–H/N–H oxidative cross-coupling/cyclization

New Paper — As the cover image of ChemComm., issue 90, 2012

Heteroaromatic imidazo[1,2-a]pyridines synthesis from C–H/N–H oxidative cross-coupling/cyclization

Chuan He , Jing Hao , Huan Xu , Yiping Mo , Huiying Liu , Juanjuan Han and Aiwen Lei

Chem. Commun., 2012, 11073-11075

DOI: 10.1039/C2CC35927H

Link: http://xlink.rsc.org/?DOI=C2CC35927H

A novel silver-mediated highly selective C–H/N–H oxidative cross-coupling/cyclization between 2-aminopyridines and terminal alkynes has been demonstrated. This approach provided a simple way to construct heteroaromatic imidazo[1,2-a]pyridines. By using this protocol, the marketed drug zolimidine (antiulcer) could be synthesized easily.