New Paper: Solvent-Enabled Radical Selectivities: Controlled Syntheses of Sulfoxides and Sulfides

New Paper:

Solvent-Enabled Radical Selectivities: Controlled Syntheses of Sulfoxides and Sulfides

Huamin Wang, Qingquan Lu, Chaohang Qian, Chao Liu, Wei Liu, Kai Chen, and Aiwen Lei

Abstract: Controlling selectivity is of central importance to radical chemistry. However, the highly reactive and unstable radical intermediates make this task especially challenging. Herein, a strategy for taming radical redox reactions has been developed, in which solvent-bonding can alter the reactivity of the generated radical intermediates and thereby drastically alter  the reaction selectivity at room temperature. Various b-oxysulfoxides and b-hydroxy sulfides can be facilely obtained, some of which are difficult to synthesize by existing methods. Notably, neither a metal catalyst nor any further additives are necessary in these processes.

anie-WHM-2016

Angew. Chem. Int. Ed. 2016, 55, 1094 –1097

Link:http://onlinelibrary.wiley.com/doi/10.1002/anie.201508729/epdf