Dr. Chao Liu

Chao Liuchao



College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei, P. R. China

Tel: (+86)-18942912425

Email: chao.liu#whu.edu.cn




09/2007-06/2012: Wuhan University, PhD Candidate of Chemistry, College of Chemistry and Molecular Sciences, Supervised by Prof. Aiwen Lei

10/2008-10/2009: Durham University, Visiting PhD student, Department of Chemistry, Supervised by Prof. Todd B. Marder

09/2003-07/2007: Wuhan University, Bachelor of Science, College of Chemistry and Molecular Sciences




06/2012 Eli Lilly Asia Outstanding Graduate Thesis Award, 1st Class

05/2012 Academic Innovation Award for Graduate Student, Special Class

05/2012 Excellent Graduate of Wuhan University

05/2012 Top Ten Academic Star Students of Wuhan University

04/2012 One of the Splendid Ten Students of Wuhan University in 2011

10/2011: Chinese Academy of Sciences Scholarship

08/2011: 7th China Youth Science and Technology Invention Prize

07/2011: Best Poster Presentation Award in OMCOS16

12/2008: Zhang Gaoyong Scholarship for Excellent Students

10/2008: China Scholarship for oversea study

07/2007: First-class prize of Excellent Dissertation for bachelor’s degree in Hubei Province


Research Experience


Jun/1/2013-Aug/31/2013 Visiting Scholar at Institute for Molecular Science. With Prof. Yasuhiro Uozumi

July/16/2013-July/27/2013 Visiting Scholar at Nagoya University. With Prof. Kenichiro Itami

07/2012-present: Postdoc Fellow of Wuhan University, Organic Chemistry. With Prof. Aiwen Lei

09/2007-06/2012: PhD student of Wuhan University, Focused on: Transition-Metal Catalyzed Cross Couplings of Activated Alkyl Halides. Supervisor – Prof. Aiwen Lei

10/2008-10/2009: Visiting PhD student of Durham University, Focused on: Structure and reactivity studies of palladium enolates. Supervisor – Prof. Todd B. Marder

02/2006-07/2007: Undergraduate student of Wuhan University, Focused on: Transition-Metal Catalyzed alpha-arylation of Carbonyl Compounds. Supervisor – Prof. Aiwen Lei




(1)  Liu, C.; Tang, S.; Lei, A.* Oxidant controlled Pd-catalysed selective oxidation of primary alcohols, Chem. Commun. 2013, 49, 1324-1326.

(2)  Liu, C.; Tang, S.; Zheng, L.; Liu, D.; Zhang, H.; Lei, A.* Covalently Bound Benzyl Ligand Promotes Selective Palladium-Catalyzed Oxidative Esterification of Aldehydes with Alcohols, Angew. Chem., Int. Ed. 2012, 51, 5662-5666.

(3)  Liu, C.; Tang, S.; Liu, D.; Yuan, J.; Zheng, L.; Meng, L.; Lei, A.* Nickel-Catalyzed Heck-Type Alkenylation of Secondary and Tertiary alpha-Carbonyl Alkyl Bromides, Angew. Chem., Int. Ed. 2012, 51, 3638-3641.

(4)  Liu, C.; Zhang, H.; Shi, W.; Lei, A.* Bond formations between two nucleophiles: Transition metal catalyzed oxidative cross-coupling reactions, Chem. Rev. 2011, 111, 1780-1824.

(5)  Liu, C.; Deng, Y.; Wang, J.; Yang, Y.; Tang, S.; Lei, A.* Palladium-Catalyzed C-C Bond Formation To Construct 1,4-Diketones under Mild Conditions, Angew. Chem., Int. Ed. 2011, 50, 7337-7341.

(6)  Liu, C.; Wang, J.; Meng, L.; Deng, Y.; Li, Y.; Lei, A.* Palladium-catalyzed aerobic oxidative direct esterification of alcohols, Angew. Chem., Int. Ed. 2011, 50, 5144-5148.

(7)  Liu, C.; Jin, L.; Lei, A.* Transition-metal-catalyzed oxidative cross-coupling reactions, Synlett 2010, 2527-2536.

(8)  Liu, C.; He, C.; Shi, W.; Chen, M.; Lei, A.* Ni-catalyzed mild arylation of alpha-halocarbonyl compounds with arylboronic acids, Org. Lett. 2007, 9, 5601-5604.

(9)  Wang, J.[+]; Liu, C.[+]; Yuan, J.; Lei, A.* Copper-Catalyzed Oxidative Coupling of Alkenes with Aldehydes: Direct Access to α,β-Unsaturated Ketones, Angew. Chem., Int. Ed. 2013, 52, 2256-2259 ([+]These authors contributed equally).

(10) Liu, D.[+]; Liu, C.[+]; Li, H.; Lei, A.* Direct Funtionalization of Tetrahydrofuran and 1,4-Dioxane: A Nickel-Catalyzed Oxidative Csp3-H Arylation, Angew. Chem., Int. Ed. 2013, 52, 4453-4456. ([+]These authors contributed equally).

(11) Tang, S.[+]; Liu, C.[+]; Lei, A.* Nickel-Catalysed Novel β, γ-Unsaturated Nitrile Synthesis, Chem. Commun. 2013, 49, 2442-2444. ([+]These authors contributed equally).

(12) Wang, L.[+]; Liu, C.[+]; Bai, R.; Pan, Y.; Lei, A.* Easy access to enamides: a mild nickel-catalysed alkene isomerization of allylamides, Chem. Commun. 2013, 49, 7923-7925 ([+]These authors contributed equally).

(13) Wang, J.[+]; Liu, C.[+]; Yuan, J.; Lei, A.* Transition-metal-free aerobic oxidation of primary alcohols to carboxylic acids, New J. Chem. 2013, 37, 1700-1703 ([+]These authors contributed equally).

(14) Shi, W.; Liu, C.; Lei, A.* Transition-metal catalyzed oxidative cross-coupling reactions to form C-C bonds involving organometallic reagents as nucleophiles, Chem. Soc. Rev. 2011, 40, 2761-2776.

(15) Jin, L.; Liu, C.; Liu, J.; Hu, F.; Lan, Y.; Batsanov, A. S.; Howard, J. A. K.; Marder, T. B.*; Lei, A.* Revelation of the Difference between Arylzinc Reagents Prepared from Aryl Grignard and Aryllithium Reagents Respectively: Kinetic and Structural Features, J. Am. Chem. Soc. 2009, 131, 16656-16657.

(16) Shi, W.; Liu, C.; Yu, Z.; Lei, A.* Alkynylation of alpha-halocarbonyl compounds —- a Stille-type cross-coupling for the formation of C(sp)-C(sp3) bonds under neutral conditions, Chem. Commun. 2007, 2342-2344.

(17) Meng, L.; Wu, K.; Liu, C.; Lei, A.* Palladium-catalysed aerobic oxidative Heck-type alkenylation of Csp3-H for pyrrole synthesis, Chem. Commun. 2013, 49, 5853-5855.

(18) Yang, Y.; Tang, S.; Liu, C.; Zhang, H.; Sun, Z.; Lei, A.* Novel alpha-arylnitriles synthesis via Ni-catalyzed cross-coupling of alpha-bromonitriles with arylboronic acids under mild conditions, Org. Biomol. Chem. 2011, 9, 5343-5345.

(19) Cao, X.; Yang, W.; Liu, C.; Wei, F.; Wu, K.; Sun, W.; Song, J.*; Xie, L.; Huang, W. Palladium-Catalyzed Direct Arylation of C-H Bond To Construct Quaternary Carbon Centers: The Synthesis of Diarylfluorene, Org. Lett. 2013, 15, 3102-3105.

(20) Shi, R.; Lu, L.; Zhang, H.; Chen, B.; Sha, Y.; Liu, C.; Lei, A.* Palladium/Copper-Catalyzed Oxidative C-H Alkenylation/N-Dealkylative Carbonylation of Tertiary Anilines, Angew. Chem., Int. Ed. 2013, DOI: 10.1002/anie.201303911.

(21) Meng, L.; Zhang, G.; Liu, C.; Wu, K.; Lei, A.* Trifluoromethanesulfonic Acid Catalyzed Synergetic Oxidative/[3+2] Cyclization of Quinones with Olefins, Angew. Chem., Int. Ed. 2013, DOI: 10.1002/anie.201305885.

(22) Lei, A.*; Liu, W.; Liu, C.; Chen, M. Arylation of unactivated arenes, Dalton Trans. 2010, 39, 10352-10361.

(23) Zhang, H.; Shi, R.; Gan, P.; Liu, C.; Ding, A.; Wang, Q.; Lei, A.* Palladium-Catalyzed Oxidative Double C-H Functionalization/Carbonylation for the Synthesis of Xanthones, Angew. Chem., Int. Ed. 2012, 51, 5204-5207.

(24) Zhang, H.; Liu, D.; Chen, C.; Liu, C.; Lei, A.* Palladium-Catalyzed Regioselective Aerobic Oxidative C-H Carbonylation of Heteroarenes under Base-free Conditions, Chem.–Eur. J. 2011, 17, 9581-9585.

(25) He, C.; Chen, C.; Cheng, J.; Liu, C.; Liu, W.; Li, Q.; Lei, A.* Aryl halide tolerated electrophilic amination of arylboronic acids with N-chloroamides catalyzed by CuCl at room temperature, Angew. Chem., Int. Ed. 2008, 47, 6414-6417.