New Paper:Copper-Catalyzed Oxidative Coupling of Alkenes with Aldehydes: Direct Access to α,β-Unsaturated Ketones

New Paper:Copper-Catalyzed Oxidative Coupling of Alkenes with Aldehydes: Direct Access to α,β-Unsaturated Ketones

Jing Wang, Dr. Chao Liu, Jiwen Yuan, Prof. Aiwen Lei*

Angew. Chem. Int. Ed. 2013 Early View

DOI: 10.1002/anie.201208920

http://onlinelibrary.wiley.com/doi/10.1002/anie.201208920/abstract

Let’s get radical: The first copper-catalyzed oxidative coupling of alkenes and aldehydes as developed. Various aldehydes were utilized as substrates to construct a,b-unsaturated ketones. A preliminary mechanistic study indicated that this reaction is likely to proceed through a single-electron transfer.