New Paper:Synergistic Catalysis in the Sonogashira Coupling Reaction: Quantitative Kinetic Investigation of Transmetalation

New Paper:Synergistic Catalysis in the Sonogashira Coupling Reaction: Quantitative Kinetic Investigation of Transmetalation

Chuan He,燡ie Ke,燞uan Xu,燩rof. Aiwen Lei

Angew. Chem. Int. Ed.?strong>2012燛arly View

DOI:?0.1002/anie.201207970

http://onlinelibrary.wiley.com/doi/10.1002/anie.201207970/abstract

Rate-limiting: The transmetalation step of the Sonogashira coupling reaction is established as the rate-limiting step. This cross-coupling is demonstrated to be a Pd-catalyzed and Cu-catalyzed synergistic process, which exhibits a first-order kinetic dependence on both the [Pd] and [Cu] catalysts.