Monthly Archives: December 2012

New Paper:Synergistic Catalysis in the Sonogashira Coupling Reaction: Quantitative Kinetic Investigation of Transmetalation

New Paper:Synergistic Catalysis in the Sonogashira Coupling Reaction: Quantitative Kinetic Investigation of Transmetalation

Chuan He,燡ie Ke,燞uan Xu,燩rof. Aiwen Lei

Angew. Chem. Int. Ed.?strong>2012燛arly View


Rate-limiting: The transmetalation step of the Sonogashira coupling reaction is established as the rate-limiting step. This cross-coupling is demonstrated to be a Pd-catalyzed and Cu-catalyzed synergistic process, which exhibits a first-order kinetic dependence on both the [Pd] and [Cu] catalysts.

New Paper:Labile Cu(I)-Catalyst/Spectator Cu(II)-Species in Copper-Catalyzed C-C Coupling Reaction: Operando IR, In situ XANES/EXAFS Evidence and Kinetic Investigations

New Paper:Labile Cu(I)-Catalyst/Spectator Cu(II)-Species in Copper-Catalyzed C-C Coupling Reaction: Operando IR, In situ XANES/EXAFS Evidence and Kinetic Investigations

Chuan He,a Guanghui Zhang,a,b Jie Ke,a Heng Zhang,a Jeffrey T. Miller,b Arthur J. Kropf,b and Aiwen Lei*,a,b

aCollege of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, P. R. China;

bChemical Science and Engineering Division, Argonne National Laboratory, 9700 S. Cass Ave., Argonne, IL 60439, USA.

J. Am. Chem. Soc.2013, ASAP

DOI: 10.1021/ja310111p

ABSTRACT: Insights toward the Cu-catalyzed C-C coupling reaction were investigated through operando IR and in situ XANES/EXAFS. It was found that the Cu(I)-complex formed from the reaction of CuI with β-diketone nucleophile was liable under the cross-coupling conditions, which is usually considered as active catalytic species. This labile Cu(I)-complex could rapidly disproportionate to the spectator Cu(II) and Cu(0) species under the reaction conditions, which was an off-cycle process. In this copper-catalyzed C-C coupling reaction, β-diketone might act both as the substrate and the ligand.

We Won the Third Postgraduate Badminton Match of CCMS!

Prof. Lei’s team won the Third Postgraduate Badminton Match of CCMS(College of Chemistry and Molecular Science, Wuhan Univ.) on Dec. 9th, 2012.

The Third Postgraduate Badminton Match of CCMS started at 9:00 a.m. on Dec. 9th, 2012. There were 16 teams in all from different laboratories participating in this match. All the athletes showed a spirited and highly motivated state during the whole match, which made this match very wonderful and worth of viewing.

The match started at 8:30 a.m. During the Group Stage, we accounted with a very strong team and a relatively weak team. After an intense race against these two teams, we beat them all and successfully qualified ranking top of the group. During the rematch at afternoon, we overcome all the difficulties in the way by virtue of our teammates’ tacit cooperation and exquisite skills, and finally beat all the other seven teams successfully winning the championship. This match not only motivated our athletic enthusiasm, but also enhanced relationships around each other.











2012化院师生羽毛球赛活力开打 雷爱文老师团队获冠军


 (图一 裁判员代表、运动员代表宣誓,比赛正式开始)


(图二 比赛精彩瞬间)


(图三 决赛角逐)



Doctoral Dissertation Defense: Liqun Jin & Yue Weng

Two excellent representatives of female Ph.D candidates in our lab gave their doctoral dissertation defenses on Dec. 5th, 2012.

The chairman of the dissertation committee is Prof. Meixiang Wang (Tsinghua University), and other four members are Prof. Liuzhu Gong (University of Science and Technology of China), Dr. Sanzhong Luo (Research Fellow of Institute of Chemstry, Chinese Academy of Science), Prof. Jingui Qin (Wuhan University) and Prof. Chunjiang Wang (Wuhan University).

First, Ms. Liqun Jin presented her work with the title of “Investigation of Some Important Physical Organic Questions in Transition-Metal-Catalyzed C-C Bond Formations”. She mainly used in-situ IR as the tool to reveal the elementary reactions involved in coupling reactions, with transition-metal-catalyzed oxidative coupling as model reactions.

Then Ms. Yue Weng presented her work with the title of “Insights Toward Transition-Metal-Catalyzed Csp-Csp Coupling Reaction Inspired by Kinetic Studies”, demonstrating an efficient Pd-catalyzed highly selective Csp-Csp cross-coupling reaction between terminal alkynes and 1-bromoacetylenes. Due to a two-year experiment in the United States in 2007-2009, the dissertation also involves the work she had done abroad.

After the presentation, Liqun Jin and Yue Weng answered the questions asked by the dissertation committee members and students.


Prof. Meixiang Wang and Prof. Liu-Zhu Gong Visited Our Lab

Prof. Meixiang Wang  (Tsinghua University)  Prof. Liu-Zhu Gong(University of Science and Technology of China) visited our lab on 5th.Dec. In the afternoon, they gave us two wonderful lectures  respectively. Prof. Wang’s lecture was entitled with “Recent Advances in Supramolecular Chemistry of Heteracaclixaromatics: Understanding of Anion-лInteractions and Copper-Catalyzed Arene C-H Bonds Activation”, and Prof Gong’s lecture’s title is “Organocatalysis Combined with Metal Catalysis”. After the lecture, they also discussed several questions with Prof. Aiwen Lei and students. We really learned a lot from Prof. Wang and Prof. Gong’s lecture. At night, Our students had a  deep discussion about their works. We really appreciated Prof. Meixiang Wang and Prof. Liu-Zhu Gong’s kind discussion and good suggestions.